Prediction of post-vaccine population structure of Streptococcus pneumoniae using accessory gene frequencies

Taj Azarian; Pamela P Martinez; Brian J Arnold; Lindsay R Grant; Jukka Corander; Christophe Fraser; Nicholas J Croucher; Laura L Hammitt; Raymond Reid; Mathuram Santosham; Robert C Weatherholtz; Stephen D Bentley; Katherine L O’Brien; Marc Lipsitch; William P Hanage

doi:10.1101/420315

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Prediction of post-vaccine population structure of Streptococcus pneumoniae using accessory gene frequencies

View ORCID ProfileTaj Azarian, View ORCID ProfilePamela P Martinez, Brian J Arnold, Lindsay R Grant, Jukka Corander, View ORCID ProfileChristophe Fraser, View ORCID ProfileNicholas J Croucher, Laura L Hammitt, Raymond Reid, Mathuram Santosham, Robert C Weatherholtz, Stephen D Bentley, Katherine L O’Brien, View ORCID ProfileMarc Lipsitch, View ORCID ProfileWilliam P Hanage

doi: https://doi.org/10.1101/420315

Taj Azarian

1Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL

2Center for Communicable Disease Dynamics, Department of Epidemiology, T.H. Chan School of Public Health, Harvard University, Boston MA

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Pamela P Martinez

2Center for Communicable Disease Dynamics, Department of Epidemiology, T.H. Chan School of Public Health, Harvard University, Boston MA

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Brian J Arnold

2Center for Communicable Disease Dynamics, Department of Epidemiology, T.H. Chan School of Public Health, Harvard University, Boston MA

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Lindsay R Grant

3Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Jukka Corander

4Helsinki Institute for Information Technology, Department of Mathematics and Statistics, University of Helsinki, 00014 Helsinki, Finland

5Department of Biostatistics, University of Oslo, 0317 Oslo, Norway

6Infection Genomics, The Wellcome Trust, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK

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Christophe Fraser

7Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LF, UK

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Nicholas J Croucher

8MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK

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Laura L Hammitt

3Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Raymond Reid

3Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Mathuram Santosham

3Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Robert C Weatherholtz

3Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Stephen D Bentley

6Infection Genomics, The Wellcome Trust, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK

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Katherine L O’Brien

3Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Marc Lipsitch

2Center for Communicable Disease Dynamics, Department of Epidemiology, T.H. Chan School of Public Health, Harvard University, Boston MA

9Department of Immunology and Infectious Diseases, T.H. Chan School of Public Health, Harvard University, Boston MA

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William P Hanage

2Center for Communicable Disease Dynamics, Department of Epidemiology, T.H. Chan School of Public Health, Harvard University, Boston MA

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Posted September 18, 2018.

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Prediction of post-vaccine population structure of Streptococcus pneumoniae using accessory gene frequencies

Taj Azarian, Pamela P Martinez, Brian J Arnold, Lindsay R Grant, Jukka Corander, Christophe Fraser, Nicholas J Croucher, Laura L Hammitt, Raymond Reid, Mathuram Santosham, Robert C Weatherholtz, Stephen D Bentley, Katherine L O’Brien, Marc Lipsitch, William P Hanage

bioRxiv 420315; doi: https://doi.org/10.1101/420315

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