New Results
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration
Xueping Liu, Dorte Helenius, Line Skotte, Robin N. Beaumont, Matthias Wielscher, Frank Geller, Julius Juodakis, Anubha Mahajan, Jonathan P. Bradfield, Frederick T.J. Lin, Suzanne Vogelezang, Mariona Bustamante, View ORCID ProfileTarunveer S. Ahluwalia, View ORCID ProfileNiina Pitkänen, Carol A. Wang, Jonas Bacelis, Maria C. Borges, Ge Zhang, Bruce A. Bedell, Robert M. Rossi, Kristin Skogstrand, Shouneng Peng, Early Growth Genetics (EGG) Consortium, iPSYCH-BROAD Working Group, Wesley K. Thompson, Vivek Appadurai, Debbie A. Lawlor, Ilkka Kalliala, Christine Power, Mark I. McCarthy, Heather A. Boyd, Mary L. Marazita, Hakon Hakonarson, M. Geoffrey Hayes, Denise M. Scholtens, Fernando Rivadeneira, Vincent W.V. Jaddoe, Rebecca K. Vinding, Hans Bisgaard, Bridget A. Knight, Katja Pahkala, Olli Raitakari, Øyvind Helgeland, Stefan Johansson, Pål R. Njølstad, João Fadista, Andrew Schork, Ron Nudel, Daniel E. Miller, View ORCID ProfileXiaoting Chen, Matthew T. Weirauch, Preben Bo Mortensen, Anders D. Børglum, Merete Nordentoft, Ole Mors, Ke Hao, Kelli K. Ryckman, David M. Hougaard, Leah C. Kottyan, Craig E. Pennell, Leo-Pekka Lyytikainen, Klaus Bønnelykke, Martine Vrijheid, Janine F. Felix, William L. Lowe Jr., Struan F.A. Grant, Elina Hyppönen, Bo Jacobsson, Marjo-Riitta Jarvelin, Louis J. Muglia, Jeffrey C. Murray, Rachel M. Freathy, Thomas M. Werge, Mads Melbye, Alfonso Buil, View ORCID ProfileBjarke Feenstra
doi: https://doi.org/10.1101/423897
Xueping Liu
1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Dorte Helenius
2iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
3Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
Line Skotte
1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Robin N. Beaumont
4Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.
Matthias Wielscher
5Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Frank Geller
1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Julius Juodakis
6Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Anubha Mahajan
7Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Jonathan P. Bradfield
8Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
9Quantinuum Research, LLC, San Diego, CA, USA.
Frederick T.J. Lin
10Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Suzanne Vogelezang
11The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
12Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
13Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Mariona Bustamante
14ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
15Universitat Pompeu Fabra (UPF), Barcelona, Spain.
16CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
Tarunveer S. Ahluwalia
17COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Niina Pitkänen
18Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland.
Carol A. Wang
19School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, New South Wales, Australia.
Jonas Bacelis
20Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Maria C. Borges
21MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
22Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Ge Zhang
23Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.
24Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.
25March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH, USA.
Bruce A. Bedell
26Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
Robert M. Rossi
25March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH, USA.
27Department of Pediatrics, University of Cincinnati College of Medicine. Cincinnati, OH, USA.
Kristin Skogstrand
2iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
28Statens Serum Institut, Center for Neonatal Screening, Department for Congenital Disorders, Copenhagen, Denmark.
Shouneng Peng
29Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
30Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
Wesley K. Thompson
2iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
3Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
Vivek Appadurai
2iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
3Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
Debbie A. Lawlor
21MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
22Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
31NIHR Bristol Biomedical Research Centre, Bristol, UK.
Ilkka Kalliala
32Department of Surgery and Cancer, IRDB, Faculty of Medicine, Imperial College, London W12 0NN, UK.
33Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 2, 00029 HUS, Finland.
Christine Power
34Population, Policy and Practice, Great Ormond Street Institute for Child Health, University College London, London, UK.
Mark I. McCarthy
7Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
35Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
36NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LJ, UK.
Heather A. Boyd
1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Mary L. Marazita
37Center for Craniofacial and Dental Genetics, Department of Oral Biology School of Dental Medicine University of Pittsburgh, Pittsburgh, PA, USA.
38Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Hakon Hakonarson
8Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
39Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
40Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
M. Geoffrey Hayes
10Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
41Department of Anthropology, Northwestern University, Evanston, IL, USA.
42Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Denise M. Scholtens
43Division of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Fernando Rivadeneira
11The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
12Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
44Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Vincent W.V. Jaddoe
11The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
12Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
13Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Rebecca K. Vinding
17COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Hans Bisgaard
17COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Bridget A. Knight
45NIHR Exeter Clinical Research Facility, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.
Katja Pahkala
18Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland.
46Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Health and Physical Activity, University of Turku, 20520 Turku, Finland.
Olli Raitakari
18Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland.
47Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 20521 Turku, Finland.
Øyvind Helgeland
48K. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
49Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
50Norwegian Institute of Public Health, Division of Health data and Digitalization, Department of Genetic Research and Bioinformatics, Oslo, Norway.
Stefan Johansson
48K. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
51Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Pål R. Njølstad
48K. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
49Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
João Fadista
1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Andrew Schork
2iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
3Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
Ron Nudel
2iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
3Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
Daniel E. Miller
52Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.
Xiaoting Chen
52Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.
Matthew T. Weirauch
27Department of Pediatrics, University of Cincinnati College of Medicine. Cincinnati, OH, USA.
52Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.
53Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.
Preben Bo Mortensen
2iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
54National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
55iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
Anders D. Børglum
2iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
55iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
56Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.
Merete Nordentoft
2iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
57Mental Health Center Copenhagen, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.
58Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ole Mors
2iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
59Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark.
Ke Hao
29Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
30Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
Kelli K. Ryckman
26Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
60Department of Epidemiology, University of Iowa, Iowa City, IA, USA.
David M. Hougaard
2iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
28Statens Serum Institut, Center for Neonatal Screening, Department for Congenital Disorders, Copenhagen, Denmark.
Leah C. Kottyan
27Department of Pediatrics, University of Cincinnati College of Medicine. Cincinnati, OH, USA.
52Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.
Craig E. Pennell
19School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, New South Wales, Australia.
Leo-Pekka Lyytikainen
61Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
62Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland.
Klaus Bønnelykke
17COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Martine Vrijheid
14ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
15Universitat Pompeu Fabra (UPF), Barcelona, Spain.
16CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
Janine F. Felix
11The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
12Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
13Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
William L. Lowe Jr.
10Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Struan F.A. Grant
8Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
39Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
40Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Elina Hyppönen
34Population, Policy and Practice, Great Ormond Street Institute for Child Health, University College London, London, UK.
63Australian Centre for Precision Health, University of South Australia Cancer Research Institute, Adelaide, Australia.
64South Australian Health and Medical Research Institute, Adelaide, Australia.
Bo Jacobsson
6Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
65Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
Marjo-Riitta Jarvelin
66Institute of Health Sciences, University of Oulu, Oulu, Finland.
67Department of Epidemiology and Biostatistics, School of Public Health, Medical Research Council-Health Protection Agency Centre for Environment and Health, Faculty of Medicine, Imperial College London, UK.
Louis J. Muglia
23Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.
24Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.
25March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH, USA.
27Department of Pediatrics, University of Cincinnati College of Medicine. Cincinnati, OH, USA.
Jeffrey C. Murray
26Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
Rachel M. Freathy
4Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.
68Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove Bristol, BS8 2BN, UK.
Thomas M. Werge
2iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
3Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
58Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mads Melbye
1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
69Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Alfonso Buil
2iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
3Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
Bjarke Feenstra
1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Abstract
The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. We conducted a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One locus on chromosome 2q13 was associated with gestational duration; the association was replicated in 9,291 additional infants (combined P = 3.96 × 10−14). Analysis of 15,536 mother-child pairs showed that the association was driven by fetal rather than maternal genotype. Functional experiments showed that the lead SNP, rs7594852, alters the binding of the HIC1 transcriptional repressor. Genes at the locus include several interleukin 1 family members with roles in pro-inflammatory pathways that are central to the process of parturition. Further understanding of the underlying mechanisms will be of great public health importance, since giving birth either before or after the window of term gestation is associated with increased morbidity and mortality.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted September 23, 2018.
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration
Xueping Liu, Dorte Helenius, Line Skotte, Robin N. Beaumont, Matthias Wielscher, Frank Geller, Julius Juodakis, Anubha Mahajan, Jonathan P. Bradfield, Frederick T.J. Lin, Suzanne Vogelezang, Mariona Bustamante, Tarunveer S. Ahluwalia, Niina Pitkänen, Carol A. Wang, Jonas Bacelis, Maria C. Borges, Ge Zhang, Bruce A. Bedell, Robert M. Rossi, Kristin Skogstrand, Shouneng Peng, Early Growth Genetics (EGG) Consortium, iPSYCH-BROAD Working Group, Wesley K. Thompson, Vivek Appadurai, Debbie A. Lawlor, Ilkka Kalliala, Christine Power, Mark I. McCarthy, Heather A. Boyd, Mary L. Marazita, Hakon Hakonarson, M. Geoffrey Hayes, Denise M. Scholtens, Fernando Rivadeneira, Vincent W.V. Jaddoe, Rebecca K. Vinding, Hans Bisgaard, Bridget A. Knight, Katja Pahkala, Olli Raitakari, Øyvind Helgeland, Stefan Johansson, Pål R. Njølstad, João Fadista, Andrew Schork, Ron Nudel, Daniel E. Miller, Xiaoting Chen, Matthew T. Weirauch, Preben Bo Mortensen, Anders D. Børglum, Merete Nordentoft, Ole Mors, Ke Hao, Kelli K. Ryckman, David M. Hougaard, Leah C. Kottyan, Craig E. Pennell, Leo-Pekka Lyytikainen, Klaus Bønnelykke, Martine Vrijheid, Janine F. Felix, William L. Lowe Jr., Struan F.A. Grant, Elina Hyppönen, Bo Jacobsson, Marjo-Riitta Jarvelin, Louis J. Muglia, Jeffrey C. Murray, Rachel M. Freathy, Thomas M. Werge, Mads Melbye, Alfonso Buil, Bjarke Feenstra
bioRxiv 423897; doi: https://doi.org/10.1101/423897
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration
Xueping Liu, Dorte Helenius, Line Skotte, Robin N. Beaumont, Matthias Wielscher, Frank Geller, Julius Juodakis, Anubha Mahajan, Jonathan P. Bradfield, Frederick T.J. Lin, Suzanne Vogelezang, Mariona Bustamante, Tarunveer S. Ahluwalia, Niina Pitkänen, Carol A. Wang, Jonas Bacelis, Maria C. Borges, Ge Zhang, Bruce A. Bedell, Robert M. Rossi, Kristin Skogstrand, Shouneng Peng, Early Growth Genetics (EGG) Consortium, iPSYCH-BROAD Working Group, Wesley K. Thompson, Vivek Appadurai, Debbie A. Lawlor, Ilkka Kalliala, Christine Power, Mark I. McCarthy, Heather A. Boyd, Mary L. Marazita, Hakon Hakonarson, M. Geoffrey Hayes, Denise M. Scholtens, Fernando Rivadeneira, Vincent W.V. Jaddoe, Rebecca K. Vinding, Hans Bisgaard, Bridget A. Knight, Katja Pahkala, Olli Raitakari, Øyvind Helgeland, Stefan Johansson, Pål R. Njølstad, João Fadista, Andrew Schork, Ron Nudel, Daniel E. Miller, Xiaoting Chen, Matthew T. Weirauch, Preben Bo Mortensen, Anders D. Børglum, Merete Nordentoft, Ole Mors, Ke Hao, Kelli K. Ryckman, David M. Hougaard, Leah C. Kottyan, Craig E. Pennell, Leo-Pekka Lyytikainen, Klaus Bønnelykke, Martine Vrijheid, Janine F. Felix, William L. Lowe Jr., Struan F.A. Grant, Elina Hyppönen, Bo Jacobsson, Marjo-Riitta Jarvelin, Louis J. Muglia, Jeffrey C. Murray, Rachel M. Freathy, Thomas M. Werge, Mads Melbye, Alfonso Buil, Bjarke Feenstra
bioRxiv 423897; doi: https://doi.org/10.1101/423897
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