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Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms
Cornelis Blauwendraat, Karl Heilbron, Costanza L. Vallerga, Sara Bandres-Ciga, Rainer von Coelln, Lasse Pihlstrøm, Javier Simón-Sánchez, Claudia Schulte, Manu Sharma, Lynne Krohn, Ari Siitonen, Hirotaka Iwaki, Hampton Leonard, Alastair J. Noyce, Manuela Tan, J. Raphael Gibbs, Dena G. Hernandez, Sonja W. Scholz, Joseph Jankovic, Lisa M. Shulman, Suzanne Lesage, Jean-Christophe Corvol, Alexis Brice, Jacobus J. van Hilten, Johan Marinus, The 23andMe Research Team, Pentti Tienari, Kari Majamaa, Mathias Toft, Donald G. Grosset, Thomas Gasser, Peter Heutink, Joshua M Shulman, Nicolas Wood, John Hardy, Huw R Morris, David A. Hinds, Jacob Gratten, Peter M. Visscher, Ziv Gan-Or, Mike A. Nalls, Andrew B. Singleton, for the International Parkinson’s Disease Genomics Consortium (IPDGC)
doi: https://doi.org/10.1101/424010
Cornelis Blauwendraat
1Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
2Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Karl Heilbron
323andMe, Inc., 899 W Evelyn Avenue, Mountain View, CA, USA
Costanza L. Vallerga
4Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia
Sara Bandres-Ciga
1Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Rainer von Coelln
5Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA
Lasse Pihlstrøm
6Department of Neurology, Oslo University Hospital, Oslo, Norway
Javier Simón-Sánchez
7Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
8German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Claudia Schulte
7Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
8German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Manu Sharma
9Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Germany
Lynne Krohn
10Department of Human Genetics, McGill University, Montreal, Quebec, Canada
11Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Ari Siitonen
12Institute of Clinical Medicine, Department of Neurology, University of Oulu, Oulu, Finland
13Department of Neurology and Medical Research Center, Oulu University Hospital, Oulu, Finland
Hirotaka Iwaki
1Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
14The Michael J Fox Foundation for Parkinson’s Research, NY, USA
Hampton Leonard
1Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Alastair J. Noyce
15Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
16Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK
Manuela Tan
16Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK
J. Raphael Gibbs
1Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Dena G. Hernandez
1Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Sonja W. Scholz
2Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Joseph Jankovic
5Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA
Lisa M. Shulman
6Department of Neurology, Oslo University Hospital, Oslo, Norway
Suzanne Lesage
17Inserm U1127, Sorbonne Universités, UPMC Univ Paris 06 UMR S1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France
Jean-Christophe Corvol
17Inserm U1127, Sorbonne Universités, UPMC Univ Paris 06 UMR S1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France
Alexis Brice
17Inserm U1127, Sorbonne Universités, UPMC Univ Paris 06 UMR S1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France
Jacobus J. van Hilten
18Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
Johan Marinus
18Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
323andMe, Inc., 899 W Evelyn Avenue, Mountain View, CA, USA
Pentti Tienari
12Institute of Clinical Medicine, Department of Neurology, University of Oulu, Oulu, Finland
13Department of Neurology and Medical Research Center, Oulu University Hospital, Oulu, Finland
Kari Majamaa
12Institute of Clinical Medicine, Department of Neurology, University of Oulu, Oulu, Finland
13Department of Neurology and Medical Research Center, Oulu University Hospital, Oulu, Finland
Mathias Toft
6Department of Neurology, Oslo University Hospital, Oslo, Norway
19Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Donald G. Grosset
20Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, UK
21Institute of Neuroscience & Psychology, University of Glasgow, Glasgow, UK
Thomas Gasser
7Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
8German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Peter Heutink
7Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
8German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Joshua M Shulman
22Departments of Molecular & Human Genetics and Neuroscience, Baylor College of Medicine, Houston, USA
23Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, USA
Nicolas Wood
17Inserm U1127, Sorbonne Universités, UPMC Univ Paris 06 UMR S1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France
John Hardy
17Inserm U1127, Sorbonne Universités, UPMC Univ Paris 06 UMR S1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France
Huw R Morris
24Department of Clinical Neuroscience, UCL Institute of Neurology, London UK
25UCL Movement Disorders Centre, UCL Institute of Neurology, London, UK
David A. Hinds
323andMe, Inc., 899 W Evelyn Avenue, Mountain View, CA, USA
Jacob Gratten
4Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia
26Queensland Brain Institute, The University of Queensland, Brisbane, Australia
Peter M. Visscher
4Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia
26Queensland Brain Institute, The University of Queensland, Brisbane, Australia
Ziv Gan-Or
10Department of Human Genetics, McGill University, Montreal, Quebec, Canada
11Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
27Department of Neurology & Neurosurgery, McGill University, Montreal, Quebec, Canada
Mike A. Nalls
1Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
28Data Tecnica International, Glen Echo, MD, USA
Andrew B. Singleton
1Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
Article usage
Posted October 11, 2018.
Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms
Cornelis Blauwendraat, Karl Heilbron, Costanza L. Vallerga, Sara Bandres-Ciga, Rainer von Coelln, Lasse Pihlstrøm, Javier Simón-Sánchez, Claudia Schulte, Manu Sharma, Lynne Krohn, Ari Siitonen, Hirotaka Iwaki, Hampton Leonard, Alastair J. Noyce, Manuela Tan, J. Raphael Gibbs, Dena G. Hernandez, Sonja W. Scholz, Joseph Jankovic, Lisa M. Shulman, Suzanne Lesage, Jean-Christophe Corvol, Alexis Brice, Jacobus J. van Hilten, Johan Marinus, The 23andMe Research Team, Pentti Tienari, Kari Majamaa, Mathias Toft, Donald G. Grosset, Thomas Gasser, Peter Heutink, Joshua M Shulman, Nicolas Wood, John Hardy, Huw R Morris, David A. Hinds, Jacob Gratten, Peter M. Visscher, Ziv Gan-Or, Mike A. Nalls, Andrew B. Singleton, for the International Parkinson’s Disease Genomics Consortium (IPDGC)
bioRxiv 424010; doi: https://doi.org/10.1101/424010
Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms
Cornelis Blauwendraat, Karl Heilbron, Costanza L. Vallerga, Sara Bandres-Ciga, Rainer von Coelln, Lasse Pihlstrøm, Javier Simón-Sánchez, Claudia Schulte, Manu Sharma, Lynne Krohn, Ari Siitonen, Hirotaka Iwaki, Hampton Leonard, Alastair J. Noyce, Manuela Tan, J. Raphael Gibbs, Dena G. Hernandez, Sonja W. Scholz, Joseph Jankovic, Lisa M. Shulman, Suzanne Lesage, Jean-Christophe Corvol, Alexis Brice, Jacobus J. van Hilten, Johan Marinus, The 23andMe Research Team, Pentti Tienari, Kari Majamaa, Mathias Toft, Donald G. Grosset, Thomas Gasser, Peter Heutink, Joshua M Shulman, Nicolas Wood, John Hardy, Huw R Morris, David A. Hinds, Jacob Gratten, Peter M. Visscher, Ziv Gan-Or, Mike A. Nalls, Andrew B. Singleton, for the International Parkinson’s Disease Genomics Consortium (IPDGC)
bioRxiv 424010; doi: https://doi.org/10.1101/424010
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