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Layer-dependent activity in human prefrontal cortex during working memory

Emily S. Finn, Laurentius Huber, David C. Jangraw, Peter A. Bandettini
doi: https://doi.org/10.1101/425249
Emily S. Finn
1Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, Md., USA
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  • For correspondence: emily.finn@nih.gov
Laurentius Huber
1Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, Md., USA
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David C. Jangraw
1Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, Md., USA
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Peter A. Bandettini
1Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, Md., USA
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Abstract

Working memory involves a series of functions: encoding a stimulus, maintaining or manipulating its representation over a delay, and finally making a behavioral response. While working memory engages dorsolateral prefrontal cortex (dlPFC), few studies have investigated whether these subfunctions are localized to different cortical depths in this region, and none have done so in humans. Here, we use high-resolution functional MRI to interrogate the layer specificity of neural activity during different epochs of a working memory task in dlPFC. We detect activity timecourses that follow the hypothesized patterns: superficial layers are preferentially active during the delay period, while deeper layers are preferentially active during the response. Results demonstrate that layer-specific fMRI can be used in higher-order brain regions to non-invasively map cognitive information processing along cortical circuitry in humans.

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Posted September 24, 2018.
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Layer-dependent activity in human prefrontal cortex during working memory
Emily S. Finn, Laurentius Huber, David C. Jangraw, Peter A. Bandettini
bioRxiv 425249; doi: https://doi.org/10.1101/425249
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Layer-dependent activity in human prefrontal cortex during working memory
Emily S. Finn, Laurentius Huber, David C. Jangraw, Peter A. Bandettini
bioRxiv 425249; doi: https://doi.org/10.1101/425249

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