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The Lineage-Specific Transcription Factor CDX2 Navigates Dynamic Chromatin to Control Distinct Stages of Intestine Development

Namit Kumar, Yu-Hwai Tsai, Lei Chen, Anbo Zhou, Kushal K. Banerjee, Madhurima Saxena, Sha Huang, Jinchuan Xing, Ramesh A. Shivdasani, Jason R. Spence, View ORCID ProfileMichael P. Verzi
doi: https://doi.org/10.1101/425827
Namit Kumar
1Rutgers, the State University of New Jersey, Department of Genetics
2Cancer Institute of New Jersey, and Human Genetics Institute of New Jersey, Piscataway, NJ, 08854, USA
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Yu-Hwai Tsai
3Department of Internal Medicine
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Lei Chen
1Rutgers, the State University of New Jersey, Department of Genetics
2Cancer Institute of New Jersey, and Human Genetics Institute of New Jersey, Piscataway, NJ, 08854, USA
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Anbo Zhou
1Rutgers, the State University of New Jersey, Department of Genetics
2Cancer Institute of New Jersey, and Human Genetics Institute of New Jersey, Piscataway, NJ, 08854, USA
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Kushal K. Banerjee
7Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA
8Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02215, USA
9Harvard Stem Cell Institute, Cambridge, MA 02139, USA
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Madhurima Saxena
7Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA
8Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02215, USA
9Harvard Stem Cell Institute, Cambridge, MA 02139, USA
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Sha Huang
3Department of Internal Medicine
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Jinchuan Xing
1Rutgers, the State University of New Jersey, Department of Genetics
2Cancer Institute of New Jersey, and Human Genetics Institute of New Jersey, Piscataway, NJ, 08854, USA
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Ramesh A. Shivdasani
7Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA
8Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02215, USA
9Harvard Stem Cell Institute, Cambridge, MA 02139, USA
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Jason R. Spence
3Department of Internal Medicine
6Department of Biomedical Engineering University of Michigan College of Engineering, Ann Arbor, MI 48109, USA
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  • For correspondence: spencejr@med.umich.edu Verzi@biology.rutgers.edu
Michael P. Verzi
1Rutgers, the State University of New Jersey, Department of Genetics
2Cancer Institute of New Jersey, and Human Genetics Institute of New Jersey, Piscataway, NJ, 08854, USA
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  • ORCID record for Michael P. Verzi
  • For correspondence: spencejr@med.umich.edu Verzi@biology.rutgers.edu
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Article Information

doi 
https://doi.org/10.1101/425827
History 
  • September 24, 2018.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Namit Kumar1,2,*,
  2. Yu-Hwai Tsai3,*,
  3. Lei Chen1,2,*,
  4. Anbo Zhou1,2,
  5. Kushal K. Banerjee7,8,9,
  6. Madhurima Saxena7,8,9,
  7. Sha Huang3,
  8. Jinchuan Xing1,2,
  9. Ramesh A. Shivdasani7,8,9,
  10. Jason R. Spence3,6,+ and
  11. Michael P. Verzi1,2,+
  1. 1Rutgers, the State University of New Jersey, Department of Genetics
  2. 2Cancer Institute of New Jersey, and Human Genetics Institute of New Jersey, Piscataway, NJ, 08854, USA
  3. 3Department of Internal Medicine
  4. 4Department of Cell and Developmental Biology
  5. 5Center for Organogenesis University of Michigan Medical School, Ann Arbor, MI 48109, USA
  6. 6Department of Biomedical Engineering University of Michigan College of Engineering, Ann Arbor, MI 48109, USA
  7. 7Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA
  8. 8Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02215, USA
  9. 9Harvard Stem Cell Institute, Cambridge, MA 02139, USA
  1. ↵+Corresponding Authors: Jason R. Spence: spencejr{at}med.umich.edu or Michael P. Verzi: Verzi{at}biology.rutgers.edu
  1. ↵* Authors contributed equally

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Posted September 24, 2018.
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The Lineage-Specific Transcription Factor CDX2 Navigates Dynamic Chromatin to Control Distinct Stages of Intestine Development
Namit Kumar, Yu-Hwai Tsai, Lei Chen, Anbo Zhou, Kushal K. Banerjee, Madhurima Saxena, Sha Huang, Jinchuan Xing, Ramesh A. Shivdasani, Jason R. Spence, Michael P. Verzi
bioRxiv 425827; doi: https://doi.org/10.1101/425827
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The Lineage-Specific Transcription Factor CDX2 Navigates Dynamic Chromatin to Control Distinct Stages of Intestine Development
Namit Kumar, Yu-Hwai Tsai, Lei Chen, Anbo Zhou, Kushal K. Banerjee, Madhurima Saxena, Sha Huang, Jinchuan Xing, Ramesh A. Shivdasani, Jason R. Spence, Michael P. Verzi
bioRxiv 425827; doi: https://doi.org/10.1101/425827

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