Commensal gut bacteria convert the immunosuppressant tacrolimus to less potent metabolites

Yukuang Guo; Camila Manoel Crnkovic; Kyoung-Jae Won; Xiaotong Yang; John Richard Lee; Jimmy Orjala; Hyunwoo Lee; Hyunyoung Jeong

doi:10.1101/426197

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Commensal gut bacteria convert the immunosuppressant tacrolimus to less potent metabolites

Yukuang Guo, Camila Manoel Crnkovic, Kyoung-Jae Won, Xiaotong Yang, John Richard Lee, Jimmy Orjala, Hyunwoo Lee, Hyunyoung Jeong

doi: https://doi.org/10.1101/426197

Yukuang Guo

1Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago

5Center for Biomolecular Sciences

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Camila Manoel Crnkovic

1Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago

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Kyoung-Jae Won

2Department of Pharmacy Practice, University of Illinois at Chicago

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Xiaotong Yang

4Department of Biopharmaceutical Sciences, University of Illinois at Chicago

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John Richard Lee

3Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine

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Jimmy Orjala

1Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago

5Center for Biomolecular Sciences

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Hyunwoo Lee

1Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago

5Center for Biomolecular Sciences

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Hyunyoung Jeong

2Department of Pharmacy Practice, University of Illinois at Chicago

4Department of Biopharmaceutical Sciences, University of Illinois at Chicago

5Center for Biomolecular Sciences

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Commensal gut bacteria convert the immunosuppressant tacrolimus to less potent metabolites

Yukuang Guo, Camila Manoel Crnkovic, Kyoung-Jae Won, Xiaotong Yang, John Richard Lee, Jimmy Orjala, Hyunwoo Lee, Hyunyoung Jeong

bioRxiv 426197; doi: https://doi.org/10.1101/426197

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Commensal gut bacteria convert the immunosuppressant tacrolimus to less potent metabolites

Yukuang Guo, Camila Manoel Crnkovic, Kyoung-Jae Won, Xiaotong Yang, John Richard Lee, Jimmy Orjala, Hyunwoo Lee, Hyunyoung Jeong

bioRxiv 426197; doi: https://doi.org/10.1101/426197

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