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Macaque anterior cingulate cortex deactivation impairs performance and alters lateral prefrontal oscillatory activities in a rule-switching task

View ORCID ProfileLiya Ma, View ORCID ProfileJason L. Chan, Kevin Johnston, Stephen G. Lomber, Stefan Everling
doi: https://doi.org/10.1101/427302
Liya Ma
1Robarts Research Institute, London, Ontario, N6A 5B7, Canada
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Jason L. Chan
2Graduate Program in Neuroscience, London, Ontario, N6A 5B7, Canada
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Kevin Johnston
3Departments of Physiology and Pharmacology, London, Ontario, N6A 5B7, Canada
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Stephen G. Lomber
3Departments of Physiology and Pharmacology, London, Ontario, N6A 5B7, Canada
4Departments of Psychology, London, Ontario, N6A 5B7, Canada
5Departments of Brain and Mind Institute, University of Western Ontario, London, Ontario, N6A 5B7, Canada
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Stefan Everling
1Robarts Research Institute, London, Ontario, N6A 5B7, Canada
2Graduate Program in Neuroscience, London, Ontario, N6A 5B7, Canada
3Departments of Physiology and Pharmacology, London, Ontario, N6A 5B7, Canada
5Departments of Brain and Mind Institute, University of Western Ontario, London, Ontario, N6A 5B7, Canada
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SUMMARY

In primates, both the dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (dlPFC) are key regions of the frontoparietal cognitive control network. To study the role of the dACC and its communication with the dlPFC in cognitive control, we recorded the local field potentials from the dlPFC before and during the reversible deactivation of the dACC, in macaque monkeys engaging in uncued switches between two stimulus-response rules. Cryogenic dACC deactivation impaired response accuracy during rule-maintenance, but not rule-switching, which coincided with a reduction in the correct-error difference in dlPFC beta activities specifically during maintenance of the more challenging rule. During both rule switching and maintenance, dACC deactivation prolonged the animals’ reaction time and reduced task-related theta/alpha activities in the dlPFC; it also weakened dlPFC theta-gamma phase-amplitude modulation. Thus, the dACC and its interaction with the dlPFC plays a critical role in the maintenance of a new, challenging rule.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted September 25, 2018.
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Macaque anterior cingulate cortex deactivation impairs performance and alters lateral prefrontal oscillatory activities in a rule-switching task
Liya Ma, Jason L. Chan, Kevin Johnston, Stephen G. Lomber, Stefan Everling
bioRxiv 427302; doi: https://doi.org/10.1101/427302
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Macaque anterior cingulate cortex deactivation impairs performance and alters lateral prefrontal oscillatory activities in a rule-switching task
Liya Ma, Jason L. Chan, Kevin Johnston, Stephen G. Lomber, Stefan Everling
bioRxiv 427302; doi: https://doi.org/10.1101/427302

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