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Reduced serotonin receptors and transporters in normal aging adults: a meta-analysis of PET and SPECT imaging studies

View ORCID ProfileTeresa M. Karrer, Casey L. McLaughlin, Carmela P. Guaglianone, View ORCID ProfileGregory R. Samanez-Larkin
doi: https://doi.org/10.1101/429266
Teresa M. Karrer
aDepartment of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen, Germany
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  • For correspondence: tkarrer@ukaachen.de
Casey L. McLaughlin
bDepartment of Biology, College of William and Mary, Williamsburg, VA, USA
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Carmela P. Guaglianone
cDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA
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Gregory R. Samanez-Larkin
cDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA
dCenter for Cognitive Neuroscience, Duke University, Durham, NC, USA
eCenter for the Study of Aging and Human Development, Duke University, Durham, NC, USA
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Abstract

Age-related alterations in serotonin (5-HT) function have been hypothesized to underlie a range of physiological, emotional, and cognitive changes in older age. Here, we conducted a quantitative synthesis and comparison of the effects of age on 5-HT receptors and transporters from cross-sectional PET and SPECT imaging studies. Random-effects meta-analyses of 31 studies including 1087 healthy adults yielded large negative age effects in 5-HT-2A receptors, moderate negative age effects in 5-HT transporters, and small negative age effects in 5-HT-1A receptors. Age differences were significantly larger in 5-HT-2A receptors compared to 5-HT-1A receptors. A meta-regression showed that 5-HT target, brain region, tracer kinetic measure, radionuclide, and publication year significantly moderated the age effect. The findings overall identify reduced serotonergic signal transmission in age. The evidence for a relative preservation of 5-HT-1A compared to 5-HT-2A receptors may partially explain differential psychological changes with age, such as why older people use more emotion-focused rather than problem-focused coping strategies.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 27, 2018.
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Reduced serotonin receptors and transporters in normal aging adults: a meta-analysis of PET and SPECT imaging studies
Teresa M. Karrer, Casey L. McLaughlin, Carmela P. Guaglianone, Gregory R. Samanez-Larkin
bioRxiv 429266; doi: https://doi.org/10.1101/429266
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Reduced serotonin receptors and transporters in normal aging adults: a meta-analysis of PET and SPECT imaging studies
Teresa M. Karrer, Casey L. McLaughlin, Carmela P. Guaglianone, Gregory R. Samanez-Larkin
bioRxiv 429266; doi: https://doi.org/10.1101/429266

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