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Layer-specific ultra-high field 7T fMRI showing that threat anticipation is mediated by the pulvinar input to the superficial layers of primary visual cortex (V1)

Ai Koizumi, Minye Zhan, Hiroshi Ban, Ikuhiro Kida, Federico de Martino, Beatrice de Gelder, Kaoru Amano
doi: https://doi.org/10.1101/431270
Ai Koizumi
1Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT), Address: 1-4 Yamadaoka, Suita City, Osaka, 565-0871, Japan
2Graduate School of Frontier Biosciences, Osaka University, Address: 1-3 Yamadaoka, Suita City, Osaka, 565-0871, Japan
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  • For correspondence: bellkoizumi@gmail.com b.degelder@maastrichtuniversity.nl
Minye Zhan
3Department of Cognitive Neuroscience, Maastricht University, Address: Oxfordlaan 55, 6229 EV Maastricht, The Netherlands
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Hiroshi Ban
1Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT), Address: 1-4 Yamadaoka, Suita City, Osaka, 565-0871, Japan
2Graduate School of Frontier Biosciences, Osaka University, Address: 1-3 Yamadaoka, Suita City, Osaka, 565-0871, Japan
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Ikuhiro Kida
1Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT), Address: 1-4 Yamadaoka, Suita City, Osaka, 565-0871, Japan
2Graduate School of Frontier Biosciences, Osaka University, Address: 1-3 Yamadaoka, Suita City, Osaka, 565-0871, Japan
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Federico de Martino
3Department of Cognitive Neuroscience, Maastricht University, Address: Oxfordlaan 55, 6229 EV Maastricht, The Netherlands
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Beatrice de Gelder
3Department of Cognitive Neuroscience, Maastricht University, Address: Oxfordlaan 55, 6229 EV Maastricht, The Netherlands
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  • For correspondence: bellkoizumi@gmail.com b.degelder@maastrichtuniversity.nl
Kaoru Amano
1Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT), Address: 1-4 Yamadaoka, Suita City, Osaka, 565-0871, Japan
2Graduate School of Frontier Biosciences, Osaka University, Address: 1-3 Yamadaoka, Suita City, Osaka, 565-0871, Japan
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Abstract

The perceptual system gives priority to threat-relevant signals with survival value. Its mechanism may not only include the processing initiated in the presence of threat signals but also in the mere anticipation of such signals. Here, we show that the pulvinar modulates activity in the early visual cortex (V1) specifically in threat anticipation. Using ultra-high-field 7T fMRI, we examined the layer-specific interaction between V1 and the pulvinar, while taking advantage of the fact that the directionality of such interaction is anatomically constrained in specific V1 layers. Only in anticipation of a fearful face target, but not of a control happy face target, was false perception of anticipated-yet-unpresented target face accompanied by stronger activity in the V1 superficial-cortical-depth (layers 1-3), which was preceded by pre-target-onset pulvinar activity. The pulvinar may contribute to the visual processing initiated in the anticipation of threat, and play an important role in anxiety.

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Posted October 02, 2018.
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Layer-specific ultra-high field 7T fMRI showing that threat anticipation is mediated by the pulvinar input to the superficial layers of primary visual cortex (V1)
Ai Koizumi, Minye Zhan, Hiroshi Ban, Ikuhiro Kida, Federico de Martino, Beatrice de Gelder, Kaoru Amano
bioRxiv 431270; doi: https://doi.org/10.1101/431270
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Layer-specific ultra-high field 7T fMRI showing that threat anticipation is mediated by the pulvinar input to the superficial layers of primary visual cortex (V1)
Ai Koizumi, Minye Zhan, Hiroshi Ban, Ikuhiro Kida, Federico de Martino, Beatrice de Gelder, Kaoru Amano
bioRxiv 431270; doi: https://doi.org/10.1101/431270

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