Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Cooperation of partially-transformed clones: the invisible force behind the early stages of carcinogenesis

View ORCID ProfileAlessandro Esposito
doi: https://doi.org/10.1101/431478
Alessandro Esposito
The Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Alessandro Esposito
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Early models and observations on the clonal origin of cancer asserted that cancer arises from a sequence of rare mutations that confer the capability to one cell, and its progeny, to grow outside the control of the tissue of origin. More recently, theories for polyclonal tumour evolution and accumulating experimental evidence have challenged this perspective. However, the role and a model for non-cell-autonomous mechanisms during mutationally-driven carcinogenesis, at the best of our knowledge, are not well characterised. Therefore, we developed a simple yet insightful theoretical framework to address the question of how frequent and important non-cell-autonomous mechanisms during the early steps in carcinogenesis might be. We show that the three-dimensional tissue architecture is likely to amplify local non-cell-autonomous mechanisms of carcinogenesis mediated by cooperation of different, non- or partially-transformed mutants. We thus propose that clonal cooperation during the earliest steps in oncogenesis is an under-appreciated process, yet a phenomenon that might be an essential force that shapes tumour evolution.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted October 02, 2018.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Cooperation of partially-transformed clones: the invisible force behind the early stages of carcinogenesis
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Cooperation of partially-transformed clones: the invisible force behind the early stages of carcinogenesis
Alessandro Esposito
bioRxiv 431478; doi: https://doi.org/10.1101/431478
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Cooperation of partially-transformed clones: the invisible force behind the early stages of carcinogenesis
Alessandro Esposito
bioRxiv 431478; doi: https://doi.org/10.1101/431478

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Cancer Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4228)
  • Biochemistry (9107)
  • Bioengineering (6751)
  • Bioinformatics (23944)
  • Biophysics (12089)
  • Cancer Biology (9495)
  • Cell Biology (13740)
  • Clinical Trials (138)
  • Developmental Biology (7616)
  • Ecology (11661)
  • Epidemiology (2066)
  • Evolutionary Biology (15479)
  • Genetics (10618)
  • Genomics (14296)
  • Immunology (9463)
  • Microbiology (22792)
  • Molecular Biology (9078)
  • Neuroscience (48889)
  • Paleontology (355)
  • Pathology (1479)
  • Pharmacology and Toxicology (2565)
  • Physiology (3823)
  • Plant Biology (8308)
  • Scientific Communication and Education (1467)
  • Synthetic Biology (2290)
  • Systems Biology (6172)
  • Zoology (1297)