Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Discrete stepping and nonlinear ramping dynamics underlie spiking responses of LIP neurons during decision-making

View ORCID ProfileDavid M. Zoltowski, Kenneth W. Latimer, View ORCID ProfileJacob L. Yates, View ORCID ProfileAlexander C. Huk, View ORCID ProfileJonathan W. Pillow
doi: https://doi.org/10.1101/433458
David M. Zoltowski
1Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08540, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for David M. Zoltowski
  • For correspondence: zoltowski@princeton.edu
Kenneth W. Latimer
2Department of Neurobiology, University of Chicago, Chicago, IL, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jacob L. Yates
3Center for Visual Science, University of Rochester, Rochester, NY, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jacob L. Yates
Alexander C. Huk
4Department of Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA
5Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA
6Center for Perceptual Systems, The University of Texas at Austin, Austin, TX 78712, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Alexander C. Huk
Jonathan W. Pillow
1Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08540, USA
7Department of Psychology, Princeton University, Princeton, NJ 08540, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jonathan W. Pillow
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Neurons in macaque area LIP exhibit gradual ramping in their trial-averaged spike responses during sensory decision-making. However, recent work has sparked debate over whether single-trial LIP spike trains are better described by discrete “stepping” or continuous drift-diffusion (“ramping”) dynamics. Here we address this controversy using powerful model-based analyses of LIP spike responses. We extended latent dynamical models of LIP spike trains to incorporate non-Poisson spiking, baseline firing rates, and various nonlinear relationships between the latent variable and firing rate. Moreover, we used advanced model-comparison methods, including cross-validation and a fully Bayesian information criterion, to evaluate and compare models. These analyses revealed that when non-Poisson spiking was incorporated into existing stepping and ramping models, a majority of neurons remained better described by stepping dynamics, even when conditioning on evidence level or choice. However, an extended ramping model with a non-zero baseline and a compressive output nonlinearity accounted for roughly as many neurons as the stepping model. The latent dynamics inferred under this model exhibited high diffusion variance for many neurons, making them qualitatively different than slowly-evolving continuous dynamics. These findings generalized to alternative tasks, suggesting that a robust fraction of LIP neurons are better described by each model class.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted October 02, 2018.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Discrete stepping and nonlinear ramping dynamics underlie spiking responses of LIP neurons during decision-making
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Discrete stepping and nonlinear ramping dynamics underlie spiking responses of LIP neurons during decision-making
David M. Zoltowski, Kenneth W. Latimer, Jacob L. Yates, Alexander C. Huk, Jonathan W. Pillow
bioRxiv 433458; doi: https://doi.org/10.1101/433458
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Discrete stepping and nonlinear ramping dynamics underlie spiking responses of LIP neurons during decision-making
David M. Zoltowski, Kenneth W. Latimer, Jacob L. Yates, Alexander C. Huk, Jonathan W. Pillow
bioRxiv 433458; doi: https://doi.org/10.1101/433458

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3701)
  • Biochemistry (7820)
  • Bioengineering (5695)
  • Bioinformatics (21343)
  • Biophysics (10603)
  • Cancer Biology (8206)
  • Cell Biology (11973)
  • Clinical Trials (138)
  • Developmental Biology (6786)
  • Ecology (10424)
  • Epidemiology (2065)
  • Evolutionary Biology (13908)
  • Genetics (9731)
  • Genomics (13108)
  • Immunology (8170)
  • Microbiology (20064)
  • Molecular Biology (7875)
  • Neuroscience (43170)
  • Paleontology (321)
  • Pathology (1282)
  • Pharmacology and Toxicology (2267)
  • Physiology (3362)
  • Plant Biology (7253)
  • Scientific Communication and Education (1316)
  • Synthetic Biology (2012)
  • Systems Biology (5550)
  • Zoology (1133)