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Dynamic alterations of retinal EphA5 expression in retinocollicular map plasticity

Qi Cheng, Mark D. Graves, View ORCID ProfileSarah L. Pallas
doi: https://doi.org/10.1101/433904
Qi Cheng
1Neuroscience Institute Georgia State University, Atlanta, GA, USA
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Mark D. Graves
2Department of Biology, Georgia State University, Atlanta, GA, USA
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Sarah L. Pallas
1Neuroscience Institute Georgia State University, Atlanta, GA, USA
2Department of Biology, Georgia State University, Atlanta, GA, USA
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  • ORCID record for Sarah L. Pallas
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Abstract

The topographically ordered retinocollicular projection is an excellent system for studying the mechanism of axon guidance. Gradients of EphA receptors in the retina and ephrin-As in the superior colliculus (SC) pattern the anteroposterior axis of the retinocollicular map, but whether they are involved in map plasticity after injury is unknown. Partial damage to the caudal SC at birth creates a compressed, complete retinotopic map in the remaining SC without affecting visual response properties. Previously, we found that the gradient of ephrinA expression in compressed maps is steeper than normal, suggesting an instructive role in compression (Tadesse et al., 2013). Here we measured EphA5 mRNA and protein levels after caudal SC damage in order to test the hypothesis that changes in retinal EphA5 expression occur that are complementary to the changes in collicular ephrin-A expression. We find that the nasotemporal gradient of EphA5 receptor expression steepens in the retina and overall expression levels change dynamically, especially in temporal retina, supporting the hypothesis. This change in receptor expression occurs after the change in ephrin-A ligand expression. We propose that changes in the retinal EphA5 gradient guide recovery of the retinocollicular projection from early injury. This could occur directly through the change in EphA5 expression instructing retino-SC map compression, or through ephrinA ligand signaling instructing a change in EphA5 receptor expression that in turn signals the retinocollicular map to compress. Understanding what molecular signals direct compensation for injury is essential to developing rehabilitative strategies and maximizing the potential for recovery.

Footnotes

  • Email Addresses: QC: bioqxc{at}gmail.com, MDG: biomdg{at}gmail.com, SLP: spallas{at}gsu.edu

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted March 01, 2019.
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Dynamic alterations of retinal EphA5 expression in retinocollicular map plasticity
Qi Cheng, Mark D. Graves, Sarah L. Pallas
bioRxiv 433904; doi: https://doi.org/10.1101/433904
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Dynamic alterations of retinal EphA5 expression in retinocollicular map plasticity
Qi Cheng, Mark D. Graves, Sarah L. Pallas
bioRxiv 433904; doi: https://doi.org/10.1101/433904

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