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Novel diamond shuttle to deliver flexible bioelectronics with reduced tissue compression

Kyounghwan Na, Zachariah J. Sperry, Jiaao Lu, Mihaly Vöröslakos, Saman S. Parizi, Tim M. Bruns, Euisik Yoon, John P. Seymour
doi: https://doi.org/10.1101/435800
Kyounghwan Na
Electrical Engineering & Computer Science Department, University of Michigan, Ann Arbor, USA
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Zachariah J. Sperry
Biomedical Engineering Department, University of Michigan, Ann Arbor, USABiointerfaces Institute, University of Michigan, Ann Arbor, USA
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Jiaao Lu
Electrical Engineering & Computer Science Department, University of Michigan, Ann Arbor, USA
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Mihaly Vöröslakos
Electrical Engineering & Computer Science Department, University of Michigan, Ann Arbor, USAThe Neuroscience Institute, New York University, New York, NY, USA
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Saman S. Parizi
Electrical Engineering & Computer Science Department, University of Michigan, Ann Arbor, USA
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Tim M. Bruns
Biomedical Engineering Department, University of Michigan, Ann Arbor, USABiointerfaces Institute, University of Michigan, Ann Arbor, USA
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Euisik Yoon
Electrical Engineering & Computer Science Department, University of Michigan, Ann Arbor, USABiomedical Engineering Department, University of Michigan, Ann Arbor, USA
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John P. Seymour
Electrical Engineering & Computer Science Department, University of Michigan, Ann Arbor, USA
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Abstract

The ability to deliver flexible biosensors through the toughest membranes of the central and peripheral nervous system is an important challenge in neuroscience and neural engineering. Bioelectronic devices implanted through dura mater and thick epineurium would ideally create minimal compression and acute damage as they reach the neurons of interest. We demonstrate that a three-dimensional diamond shuttle can be easily made with a vertical support to deliver ultra-compliant polymer microelectrodes (4.5 μm thick) in-vivo through dura mater and thick epineurium. The diamond shuttle has 54% less cross-sectional area than an equivalently stiff silicon shuttle, which we simulated will result in a 37% reduction in blood vessel damage. We also discovered that higher frequency oscillation of the shuttle (200 Hz) significantly reduced tissue compression regardless of the insertion speed, while slow speeds also independently reduced tissue compression. Insertion and recording performance are demonstrated in rat and feline models, but the large design space of these tools are suitable for research in a variety of animal models and nervous system targets.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted October 17, 2018.
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Novel diamond shuttle to deliver flexible bioelectronics with reduced tissue compression
Kyounghwan Na, Zachariah J. Sperry, Jiaao Lu, Mihaly Vöröslakos, Saman S. Parizi, Tim M. Bruns, Euisik Yoon, John P. Seymour
bioRxiv 435800; doi: https://doi.org/10.1101/435800
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Novel diamond shuttle to deliver flexible bioelectronics with reduced tissue compression
Kyounghwan Na, Zachariah J. Sperry, Jiaao Lu, Mihaly Vöröslakos, Saman S. Parizi, Tim M. Bruns, Euisik Yoon, John P. Seymour
bioRxiv 435800; doi: https://doi.org/10.1101/435800

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