New Results
Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation
Jessica N. Spradlin, Xirui Hu, Carl C. Ward, Scott M. Brittain, Michael D. Jones, Lisha Ou, Milton To, Andrew Proudfoot, Elizabeth Ornelas, Mikias Woldegiorgis, James A. Olzmann, Dirksen E. Bussiere, Jason R. Thomas, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, View ORCID ProfileThomas J. Maimone, View ORCID ProfileDaniel K. Nomura
doi: https://doi.org/10.1101/436998
Jessica N. Spradlin
1Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720
2Novartis-Berkeley Center for Proteomics and Chemistry Technologies
Xirui Hu
1Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720
2Novartis-Berkeley Center for Proteomics and Chemistry Technologies
Carl C. Ward
2Novartis-Berkeley Center for Proteomics and Chemistry Technologies
3Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720
Scott M. Brittain
2Novartis-Berkeley Center for Proteomics and Chemistry Technologies
4Novartis Institutes for BioMedical Research, Cambridge, MA 02139
Michael D. Jones
2Novartis-Berkeley Center for Proteomics and Chemistry Technologies
4Novartis Institutes for BioMedical Research, Cambridge, MA 02139
Lisha Ou
1Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720
2Novartis-Berkeley Center for Proteomics and Chemistry Technologies
Milton To
5Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720
Andrew Proudfoot
6Novartis Institutes for BioMedical Research, Emeryville, CA 94608
Elizabeth Ornelas
6Novartis Institutes for BioMedical Research, Emeryville, CA 94608
Mikias Woldegiorgis
6Novartis Institutes for BioMedical Research, Emeryville, CA 94608
James A. Olzmann
5Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720
Dirksen E. Bussiere
2Novartis-Berkeley Center for Proteomics and Chemistry Technologies
6Novartis Institutes for BioMedical Research, Emeryville, CA 94608
Jason R. Thomas
2Novartis-Berkeley Center for Proteomics and Chemistry Technologies
4Novartis Institutes for BioMedical Research, Cambridge, MA 02139
7Vertex Pharmaceuticals, Boston, MA 02210
John A. Tallarico
2Novartis-Berkeley Center for Proteomics and Chemistry Technologies
4Novartis Institutes for BioMedical Research, Cambridge, MA 02139
Jeffrey M. McKenna
2Novartis-Berkeley Center for Proteomics and Chemistry Technologies
4Novartis Institutes for BioMedical Research, Cambridge, MA 02139
Markus Schirle
2Novartis-Berkeley Center for Proteomics and Chemistry Technologies
4Novartis Institutes for BioMedical Research, Cambridge, MA 02139
Thomas J. Maimone
1Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720
2Novartis-Berkeley Center for Proteomics and Chemistry Technologies
Daniel K. Nomura
1Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720
2Novartis-Berkeley Center for Proteomics and Chemistry Technologies
3Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720
5Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720
Article usage
Posted April 09, 2019.
Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation
Jessica N. Spradlin, Xirui Hu, Carl C. Ward, Scott M. Brittain, Michael D. Jones, Lisha Ou, Milton To, Andrew Proudfoot, Elizabeth Ornelas, Mikias Woldegiorgis, James A. Olzmann, Dirksen E. Bussiere, Jason R. Thomas, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, Thomas J. Maimone, Daniel K. Nomura
bioRxiv 436998; doi: https://doi.org/10.1101/436998
Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation
Jessica N. Spradlin, Xirui Hu, Carl C. Ward, Scott M. Brittain, Michael D. Jones, Lisha Ou, Milton To, Andrew Proudfoot, Elizabeth Ornelas, Mikias Woldegiorgis, James A. Olzmann, Dirksen E. Bussiere, Jason R. Thomas, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, Thomas J. Maimone, Daniel K. Nomura
bioRxiv 436998; doi: https://doi.org/10.1101/436998
Subject Area
Subject Areas
- Biochemistry (11703)
- Bioengineering (8718)
- Bioinformatics (29127)
- Biophysics (14930)
- Cancer Biology (12048)
- Cell Biology (17353)
- Clinical Trials (138)
- Developmental Biology (9406)
- Ecology (14143)
- Epidemiology (2067)
- Evolutionary Biology (18266)
- Genetics (12219)
- Genomics (16765)
- Immunology (11841)
- Microbiology (28003)
- Molecular Biology (11551)
- Neuroscience (60804)
- Paleontology (450)
- Pathology (1864)
- Pharmacology and Toxicology (3229)
- Physiology (4939)
- Plant Biology (10383)
- Synthetic Biology (2877)
- Systems Biology (7333)
- Zoology (1642)