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Cytoskeletal tension actively sustains the migratory T cell synaptic contact

Sudha Kumari, Michael Mak, Yehchuin Poh, Mira Tohme, Nicki Watson, Mariane Melo, Erin Janssen, Michael Dustin, Raif Geha, Darrell J. Irvine
doi: https://doi.org/10.1101/437236
Sudha Kumari
1Koch Institute of Integrative Research, MIT, Cambridge, MA
2Ragon Institute of Harvard, MIT and MGH, Cambridge, MA
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  • For correspondence: kumars04@mit.edu djirvine@mit.edu
Michael Mak
3Department of Mechanical Engineering, MIT, Cambridge, MA
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Yehchuin Poh
1Koch Institute of Integrative Research, MIT, Cambridge, MA
3Department of Mechanical Engineering, MIT, Cambridge, MA
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Mira Tohme
4Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA
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Nicki Watson
5Whitehead Institute of Biomedical Research, Cambridge, MA
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Mariane Melo
1Koch Institute of Integrative Research, MIT, Cambridge, MA
2Ragon Institute of Harvard, MIT and MGH, Cambridge, MA
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Erin Janssen
4Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA
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Michael Dustin
6Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK
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Raif Geha
4Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA
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Darrell J. Irvine
1Koch Institute of Integrative Research, MIT, Cambridge, MA
2Ragon Institute of Harvard, MIT and MGH, Cambridge, MA
7Department of Biological engineering, MIT, Cambridge, MA
8Howard Hughes Medical Institute, Chevy Chase, MD
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  • For correspondence: kumars04@mit.edu djirvine@mit.edu
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Article Information

doi 
https://doi.org/10.1101/437236
History 
  • May 4, 2019.

Article Versions

  • Version 1 (October 8, 2018 - 08:17).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Sudha Kumari1,2,*,
  2. Michael Mak3,†,
  3. Yehchuin Poh1,3,
  4. Mira Tohme4,
  5. Nicki Watson5,
  6. Mariane Melo1,2,
  7. Erin Janssen4,
  8. Michael Dustin6,
  9. Raif Geha4 and
  10. Darrell J. Irvine1,2,7,8,*
  1. 1Koch Institute of Integrative Research, MIT, Cambridge, MA
  2. 2Ragon Institute of Harvard, MIT and MGH, Cambridge, MA
  3. 3Department of Mechanical Engineering, MIT, Cambridge, MA
  4. 4Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA
  5. 5Whitehead Institute of Biomedical Research, Cambridge, MA
  6. 6Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK
  7. 7Department of Biological engineering, MIT, Cambridge, MA
  8. 8Howard Hughes Medical Institute, Chevy Chase, MD
  1. ↵*Correspondence to kumars04{at}mit.edu; djirvine{at}mit.edu.
  • ↵† Department of Biomedical Engineering, Yale University, New Haven, CT.

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Posted May 04, 2019.
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Cytoskeletal tension actively sustains the migratory T cell synaptic contact
Sudha Kumari, Michael Mak, Yehchuin Poh, Mira Tohme, Nicki Watson, Mariane Melo, Erin Janssen, Michael Dustin, Raif Geha, Darrell J. Irvine
bioRxiv 437236; doi: https://doi.org/10.1101/437236
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Cytoskeletal tension actively sustains the migratory T cell synaptic contact
Sudha Kumari, Michael Mak, Yehchuin Poh, Mira Tohme, Nicki Watson, Mariane Melo, Erin Janssen, Michael Dustin, Raif Geha, Darrell J. Irvine
bioRxiv 437236; doi: https://doi.org/10.1101/437236

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