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Hidden ‘risk’ in polygenic scores: clinical use today could exacerbate health disparities
View ORCID ProfileAlicia R. Martin, Masahiro Kanai, Yoichiro Kamatani, Yukinori Okada, Benjamin M. Neale, Mark J. Daly
doi: https://doi.org/10.1101/441261
Alicia R. Martin
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Masahiro Kanai
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA
5Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan
Yoichiro Kamatani
5Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan
6Kyoto-McGill International Collaborative School in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Yukinori Okada
5Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan
7Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan
8Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita 565-0871, Japan
Benjamin M. Neale
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Mark J. Daly
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
3Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
9Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Posted October 11, 2018.
Hidden ‘risk’ in polygenic scores: clinical use today could exacerbate health disparities
Alicia R. Martin, Masahiro Kanai, Yoichiro Kamatani, Yukinori Okada, Benjamin M. Neale, Mark J. Daly
bioRxiv 441261; doi: https://doi.org/10.1101/441261
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