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Nanopore formation in the cuticle of the insect olfactory sensillum

Toshiya Ando, Sayaka Sekine, Sachi Inagaki, Kazuyo Misaki, Laurent Badel, Hiroyuki Moriya, Sami M Mustafa, Takahiro Chihara, Hokto Kazama, Shigenobu Yonemura, View ORCID ProfileShigeo Hayashi
doi: https://doi.org/10.1101/444729
Toshiya Ando
National Institute of Basic Biology, Okazaki, Japan;
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Sayaka Sekine
RIKEN Center for Biosystems Dynamics Research;
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Sachi Inagaki
RIKEN Center for Biosystems Dynamics Research;
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Kazuyo Misaki
RIKEN Center for Biosystems Dynamics Research;
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Laurent Badel
RIKEN Center for Brain Science;
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Hiroyuki Moriya
Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo;
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Sami M Mustafa
RIKEN Center for Biosystems Dynamics Research;
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Takahiro Chihara
University of Hiroshima
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Hokto Kazama
RIKEN Center for Brain Science;
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Shigenobu Yonemura
RIKEN Center for Biosystems Dynamics Research;
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Shigeo Hayashi
RIKEN Center for Biosystems Dynamics Research;
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  • ORCID record for Shigeo Hayashi
  • For correspondence: shigeo.hayashi@riken.jp
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Abstract

Insects sense odorants through small (50-200-nm diameter) pores in the cuticle covering the olfactory sensilla. These nanopores serve as a filter, preventing the entry of larger airborne particles and limiting water loss. Here we show that the nanopores in Drosophila originate from a curved ultrathin film formed in the outermost layer of the cuticle, secreted from specialized plasma membrane protrusions. The gore-tex/Osiris23 gene, encoding an endosomal protein, is required for nanopore formation and odor receptivity, and is expressed specifically in developing olfactory shaft cells. The 24-member Osiris gene family is expressed in various cuticle-secreting cells, and is found only in insect genomes. Some Osiris mutants show defective cuticle-associated functions, suggesting that Osiris genes may provide a platform for investigating functional surface nano-fabrication in insects.

Footnotes

  • Typeo in the author list was corrected.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted October 18, 2018.
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Nanopore formation in the cuticle of the insect olfactory sensillum
Toshiya Ando, Sayaka Sekine, Sachi Inagaki, Kazuyo Misaki, Laurent Badel, Hiroyuki Moriya, Sami M Mustafa, Takahiro Chihara, Hokto Kazama, Shigenobu Yonemura, Shigeo Hayashi
bioRxiv 444729; doi: https://doi.org/10.1101/444729
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Nanopore formation in the cuticle of the insect olfactory sensillum
Toshiya Ando, Sayaka Sekine, Sachi Inagaki, Kazuyo Misaki, Laurent Badel, Hiroyuki Moriya, Sami M Mustafa, Takahiro Chihara, Hokto Kazama, Shigenobu Yonemura, Shigeo Hayashi
bioRxiv 444729; doi: https://doi.org/10.1101/444729

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