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Subtraction and division of visual cortical population responses by the serotonergic system

Zohre Azimi, Katharina Spoida, Ruxandra Barzan, Patric Wollenweber, Melanie D. Mark, Stefan Herlitze, View ORCID ProfileDirk Jancke
doi: https://doi.org/10.1101/444943
Zohre Azimi
1Optical Imaging Group, Institut für Neuroinformatik, Ruhr University Bochum, 44801 Bochum, Germany
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Katharina Spoida
2Department of General Zoology and Neurobiology, Ruhr University Bochum, 44780 Bochum, Germany
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Ruxandra Barzan
1Optical Imaging Group, Institut für Neuroinformatik, Ruhr University Bochum, 44801 Bochum, Germany
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Patric Wollenweber
2Department of General Zoology and Neurobiology, Ruhr University Bochum, 44780 Bochum, Germany
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Melanie D. Mark
2Department of General Zoology and Neurobiology, Ruhr University Bochum, 44780 Bochum, Germany
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Stefan Herlitze
2Department of General Zoology and Neurobiology, Ruhr University Bochum, 44780 Bochum, Germany
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Dirk Jancke
1Optical Imaging Group, Institut für Neuroinformatik, Ruhr University Bochum, 44801 Bochum, Germany
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  • ORCID record for Dirk Jancke
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Abstract

Normalization is a fundamental operation throughout neuronal systems to adjust dynamic range. In the visual cortex various cell circuits have been identified that provide the substrate for such a canonical function, but how these circuits are orchestrated remains unclear. Here we suggest the serotonergic (5-HT) system as another player involved in normalization. 5-HT receptors of different classes are co-distributed across different cortical cell types, but their individual contribution to cortical population responses is unknown. We combined wide-field calcium imaging of primary visual cortex (V1) with optogenetic stimulation of 5-HT neurons in mice dorsal raphe nucleus (DRN) — the major hub for widespread release of serotonin across cortex — in combination with selective 5-HT receptor blockers. While inhibitory (5-HT1A) receptors accounted for subtractive suppression of spontaneous activity, depolarizing (5-HT2A) receptors promoted divisive suppression of response gain. Added linearly, these components led to normalization of population responses over a range of visual contrasts.

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Posted October 16, 2018.
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Subtraction and division of visual cortical population responses by the serotonergic system
Zohre Azimi, Katharina Spoida, Ruxandra Barzan, Patric Wollenweber, Melanie D. Mark, Stefan Herlitze, Dirk Jancke
bioRxiv 444943; doi: https://doi.org/10.1101/444943
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Subtraction and division of visual cortical population responses by the serotonergic system
Zohre Azimi, Katharina Spoida, Ruxandra Barzan, Patric Wollenweber, Melanie D. Mark, Stefan Herlitze, Dirk Jancke
bioRxiv 444943; doi: https://doi.org/10.1101/444943

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