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Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans

View ORCID ProfileF. Javier Bernardo-Garcia, Maryam Syed, View ORCID ProfileGaspar Jekely, Simon G Sprecher
doi: https://doi.org/10.1101/446161
F. Javier Bernardo-Garcia
University of Fribourg;
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Maryam Syed
University of Fribourg;
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Gaspar Jekely
University of Exeter
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Simon G Sprecher
University of Fribourg;
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  • For correspondence: simon.sprecher@gmail.com
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Abstract

Across metazoans, visual systems employ different types of photoreceptor neurons to detect light. These include rhabdomeric PRs, which exist in distantly related phyla and possess an evolutionarily conserved phototransduction cascade. While the development of rhabdomeric PRs has been thoroughly studied in the fruit fly Drosophila melanogaster, we still know very little about how they form in other species. To investigate this question, we tested whether the transcription factor Glass, which is crucial for instructing rhabdomeric PR formation in Drosophila, may play a similar role in other metazoans. Glass homologues exist throughout the animal kingdom, indicating that this protein evolved prior to the metazoan radiation. Interestingly, our work indicates that glass is not expressed in rhabdomeric photoreceptors in the planarian Schmidtea mediterranea nor in the annelid Platynereis dumerilii. Combined with a comparative analysis of the Glass DNA-binding domain, our data suggest that the fate of rhabdomeric PRs is controlled by Glass-dependent and Glass-independent mechanisms in different animal clades.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted February 05, 2019.
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Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans
F. Javier Bernardo-Garcia, Maryam Syed, Gaspar Jekely, Simon G Sprecher
bioRxiv 446161; doi: https://doi.org/10.1101/446161
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Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans
F. Javier Bernardo-Garcia, Maryam Syed, Gaspar Jekely, Simon G Sprecher
bioRxiv 446161; doi: https://doi.org/10.1101/446161

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