Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Characteristic Localization of Neuronatin in Rat Tissues

Naoko Kanno, Saishu Yoshida, Takako Kato, Yukio Kato
doi: https://doi.org/10.1101/447169
Naoko Kanno
1 Division of Life Science, Meiji University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Saishu Yoshida
3 Institute of Endocrinology, Meiji University, Kanagawa, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Takako Kato
3 Institute of Endocrinology, Meiji University, Kanagawa, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yukio Kato
1 Division of Life Science, Meiji University
2 Graduate School of Agriculture, Meiji University
3 Institute of Endocrinology, Meiji University, Kanagawa, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Summary

Neuronatin (Nnat) is expressed in the pituitary, pancreas, and other tissues; however, the function of NNAT is still unclear. Recent studies have demonstrated that NNAT is localized in the sex determining region Y-box 2-positive stem/progenitor cells in the developing rat pituitary primordium and is downregulated during differentiation into mature hormone-producing cells. Moreover, NNAT is widely localized in subcellular organelles, excluding the Golgi. Here, we further evaluated NNAT expression and intracellular localization in embryonic and postnatal rat tissues such as the pancreas, tongue, whisker hair follicle, and testis. Immunohistochemistry showed that NNAT was localized in undifferentiated cells (i.e., epithelial basal cells and basement cells in the papillae of the tongue and round and elongated spermatids of the testis) as well as in differentiated cells (insulin-positive cells and exocrine cells of the pancreas, taste receptor cells of the fungiform papilla, the inner root sheath of whisker hair follicles, and spermatozoa). Additionally, NNAT showed novel intracellular localization in acrosomes in the spermatozoa. Because the endoplasmic reticulum (ER) is excluded from spermatozoa and sarco/ER Ca2+-ATPase isoform 2 (SERCA2) is absent from the inner root sheath, these findings suggested that NNAT localization in the ER and its interaction with SERCA2 were cell-or tissue-specific properties.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted October 19, 2018.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Characteristic Localization of Neuronatin in Rat Tissues
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Characteristic Localization of Neuronatin in Rat Tissues
Naoko Kanno, Saishu Yoshida, Takako Kato, Yukio Kato
bioRxiv 447169; doi: https://doi.org/10.1101/447169
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Characteristic Localization of Neuronatin in Rat Tissues
Naoko Kanno, Saishu Yoshida, Takako Kato, Yukio Kato
bioRxiv 447169; doi: https://doi.org/10.1101/447169

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Developmental Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (2413)
  • Biochemistry (4773)
  • Bioengineering (3317)
  • Bioinformatics (14620)
  • Biophysics (6610)
  • Cancer Biology (5153)
  • Cell Biology (7401)
  • Clinical Trials (138)
  • Developmental Biology (4337)
  • Ecology (6857)
  • Epidemiology (2057)
  • Evolutionary Biology (9873)
  • Genetics (7326)
  • Genomics (9494)
  • Immunology (4533)
  • Microbiology (12625)
  • Molecular Biology (4916)
  • Neuroscience (28200)
  • Paleontology (198)
  • Pathology (802)
  • Pharmacology and Toxicology (1380)
  • Physiology (2011)
  • Plant Biology (4470)
  • Scientific Communication and Education (974)
  • Synthetic Biology (1295)
  • Systems Biology (3902)
  • Zoology (722)