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Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

Urmo Võsa, Annique Claringbould, Harm-Jan Westra, Marc Jan Bonder, Patrick Deelen, Biao Zeng, Holger Kirsten, Ashis Saha, Roman Kreuzhuber, Silva Kasela, Natalia Pervjakova, Isabel Alvaes, Marie-Julie Fave, Mawusse Agbessi, Mark Christiansen, Rick Jansen, Ilkka Seppälä, Lin Tong, Alexander Teumer, Katharina Schramm, Gibran Hemani, Joost Verlouw, Hanieh Yaghootkar, Reyhan Sönmez, Andrew Brown, Viktorija Kukushkina, Anette Kalnapenkis, Sina Rüeger, Eleonora Porcu, Jaanika Kronberg-Guzman, Johannes Kettunen, Joseph Powell, Bernett Lee, Futao Zhang, Wibowo Arindrarto, Frank Beutner, BIOS Consortium, Harm Brugge, i2QTL Consortium, Julia Dmitreva, Mahmoud Elansary, Benjamin P. Fairfax, Michel Georges, Bastiaan T. Heijmans, Mika Kähönen, Yungil Kim, Julian C. Knight, Peter Kovacs, Knut Krohn, Shuang Li, Markus Loeffler, Urko M. Marigorta, Hailang Mei, Yukihide Momozawa, Martina Müller-Nurasyid, Matthias Nauck, Michel Nivard, Brenda Penninx, Jonathan Pritchard, Olli Raitakari, Olaf Rotzchke, Eline P. Slagboom, Coen D.A. Stehouwer, Michael Stumvoll, Patrick Sullivan, Peter A.C. ‘t Hoen, Joachim Thiery, Anke Tönjes, Jenny van Dongen, Maarten van Iterson, Jan Veldink, Uwe Völker, Cisca Wijmenga, Morris Swertz, Anand Andiappan, Grant W. Montgomery, Samuli Ripatti, Markus Perola, Zoltan Kutalik, Emmanouil Dermitzakis, Sven Bergmann, Timothy Frayling, Joyce van Meurs, Holger Prokisch, Habibul Ahsan, Brandon Pierce, Terho Lehtimäki, Dorret Boomsma, Bruce M. Psaty, Sina A. Gharib, Philip Awadalla, Lili Milani, Willem Ouwehand, Kate Downes, Oliver Stegle, Alexis Battle, Jian Yang, Peter M. Visscher, Markus Scholz, Gregory Gibson, Tõnu Esko, Lude Franke
doi: https://doi.org/10.1101/447367

Article Information

doi 
https://doi.org/10.1101/447367
History 
  • October 19, 2018.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Urmo Võsa*,#,1,2,
  2. Annique Claringbould*,#,1,
  3. Harm-Jan Westra**,1,
  4. Marc Jan Bonder**,1,
  5. Patrick Deelen**,1,3,
  6. Biao Zeng4,
  7. Holger Kirsten5,
  8. Ashis Saha6,
  9. Roman Kreuzhuber7,8,
  10. Silva Kasela2,
  11. Natalia Pervjakova2,
  12. Isabel Alvaes9,
  13. Marie-Julie Fave9,
  14. Mawusse Agbessi9,
  15. Mark Christiansen10,
  16. Rick Jansen11,
  17. Ilkka Seppälä12,
  18. Lin Tong13,
  19. Alexander Teumer14,
  20. Katharina Schramm15,16,
  21. Gibran Hemani17,
  22. Joost Verlouw18,
  23. Hanieh Yaghootkar19,
  24. Reyhan Sönmez20,21,
  25. Andrew Brown22,23,21,
  26. Viktorija Kukushkina2,
  27. Anette Kalnapenkis2,
  28. Sina Rüeger24,
  29. Eleonora Porcu24,
  30. Jaanika Kronberg-Guzman2,
  31. Johannes Kettunen25,
  32. Joseph Powell26,
  33. Bernett Lee27,
  34. Futao Zhang28,
  35. Wibowo Arindrarto29,
  36. Frank Beutner30,
  37. BIOS Consortium,
  38. Harm Brugge1,
  39. i2QTL Consortium,
  40. Julia Dmitreva31,
  41. Mahmoud Elansary31,
  42. Benjamin P. Fairfax32,
  43. Michel Georges31,
  44. Bastiaan T. Heijmans29,
  45. Mika Kähönen33,
  46. Yungil Kim34,35,
  47. Julian C. Knight32,
  48. Peter Kovacs36,
  49. Knut Krohn37,
  50. Shuang Li1,
  51. Markus Loeffler5,
  52. Urko M. Marigorta4,
  53. Hailang Mei38,
  54. Yukihide Momozawa31,39,
  55. Martina Müller-Nurasyid15,16,40,
  56. Matthias Nauck41,
  57. Michel Nivard42,
  58. Brenda Penninx11,
  59. Jonathan Pritchard43,
  60. Olli Raitakari44,
  61. Olaf Rotzchke27,
  62. Eline P. Slagboom29,
  63. Coen D.A. Stehouwer45,
  64. Michael Stumvoll46,
  65. Patrick Sullivan47,
  66. Peter A.C. ‘t Hoen48,
  67. Joachim Thiery49,
  68. Anke Tönjes46,
  69. Jenny van Dongen11,
  70. Maarten van Iterson29,
  71. Jan Veldink50,
  72. Uwe Völker51,
  73. Cisca Wijmenga1,
  74. Morris Swertz3,
  75. Anand Andiappan27,
  76. Grant W. Montgomery52,
  77. Samuli Ripatti53,
  78. Markus Perola54,
  79. Zoltan Kutalik24,
  80. Emmanouil Dermitzakis22,23,21,
  81. Sven Bergmann20,21,
  82. Timothy Frayling19,
  83. Joyce van Meurs18,
  84. Holger Prokisch55,56,
  85. Habibul Ahsan13,
  86. Brandon Pierce13,
  87. Terho Lehtimäki12,
  88. Dorret Boomsma11,
  89. Bruce M. Psaty10,57,
  90. Sina A. Gharib58,10,
  91. Philip Awadalla9,
  92. Lili Milani2,
  93. Willem Ouwehand7,59,
  94. Kate Downes7,
  95. Oliver Stegle8,60,61,
  96. Alexis Battle62,
  97. Jian Yang28,63,
  98. Peter M. Visscher28,
  99. Markus Scholz5,
  100. Gregory Gibson4,
  101. Tõnu Esko2 and
  102. Lude Franke#,1
  1. 1 Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands
  2. 2 Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia
  3. 3 Genomics Coordination Center, University Medical Centre Groningen, Groningen, The Netherlands
  4. 4 School of Biological Sciences, Georgia Tech, Atlanta, United States of America
  5. 5 Institut für Medizinische InformatiK, Statistik und Epidemiologie, LIFE - Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
  6. 6 Department of Computer Science, Johns Hopkins University, Baltimore, United States of America
  7. 7 Department of Haematology, University of Cambridge and NHS Blood and Transplant Cambridge Biomedical Campus, Cambridge, United Kingdom
  8. 8 European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
  9. 9 Computational Biology, Ontario Institute for Cancer Research, Toronto, Canada
  10. 10 Cardiovascular Health Research Unit, University of Washington, Seattle, United States of America
  11. 11 Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
  12. 12 Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
  13. 13 Department of Public Health Sciences, University of Chicago, Chicago, United States of America
  14. 14 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
  15. 15 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
  16. 16 Department of Medicine I, University Hospital Munich, Ludwig Maximilian’s University, München, Germany
  17. 17 MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
  18. 18 Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
  19. 19 Exeter Medical School, University of Exeter, Exeter, United Kingdom
  20. 20 Department of Computational Biology, University of Lausanne, 1015 Lausanne, Switzerland
  21. 21 Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
  22. 22 Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
  23. 23 Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland
  24. 24 Lausanne University Hospital, Lausanne, Switzerland
  25. 25 University of Helsinki, Helsinki, Finland
  26. 26 Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, Australia
  27. 27 Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore
  28. 28 Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
  29. 29 Leiden University Medical Center, Leiden, The Netherlands
  30. 30 Heart Center Leipzig, Universität Leipzig, Leipzig, Germany
  31. 31 Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liege, 1 Avenue de l’Hôpital, Liège 4000, Belgium
  32. 32 Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
  33. 33 Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
  34. 34 Department of Computer Science, Johns Hopkins University, Baltimore, United States of America
  35. 35 Genetics and Genomic Science Department, Icahn School of Medicine at Mount Sinai, New York, United States of America
  36. 36 IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany
  37. 37 Interdisciplinary Center for Clinical Research, Faculty of Medicine, Universität Leipzig, Leipzig, Germany
  38. 38 Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
  39. 39 Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan
  40. 40 DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
  41. 41 Institute of Clinical Chemistry and Laboratory Medicine, Greifswald University Hospital, Greifswald, Germany
  42. 42 Faculty of Genes, Behavior and Health, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
  43. 43 Stanford University, Stanford, United States of America
  44. 44 Turku University Hospital and University of Turku, Turku, Finland
  45. 45 Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
  46. 46 Department of Medicine, Universität Leipzig, Leipzig, Germany
  47. 47 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  48. 48 Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands
  49. 49 Institute for Laboratory Medicine, LIFE - Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
  50. 50 University Medical Center Utrecht, Utrecht, The Netherlands
  51. 51 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
  52. 52 Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
  53. 53 Statistical and Translational Genetics, University of Helsinki, Helsinki, Finland
  54. 54 National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland
  55. 55 Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany
  56. 56 Institute of Human Genetics, Technical University Munich, Munich, Germany.
  57. 57 Kaiser Permanente Washington Health Research Institute, Seattle, WA, United States of America
  58. 58 Department of Medicine, University of Washington, Seattle, United States of America
  59. 59 Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton Cambridge, United Kingdom
  60. 60 Genome Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
  61. 61 Division of Computational Genomics and Systems Genetics, German Cancer Research Center, 69120 Heidelberg, Germany
  62. 62 Departments of Biomedical Engineering and Computer Science, Johns Hopkins University, Baltimore, United States of America
  63. 63 Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
  1. ↵# Correspondence can be addressed to Urmo VÕsa (urmo.vosa{at}gmail.com) Annique Claringbould (anniqueclaringbould{at}gmail.com) Lude Franke(ludefranke{at}gmail.com)

  1. ↵* These authors contributed equally to this work.

  2. ↵** These authors contributed equally to this work.

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Posted October 19, 2018.
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Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis
Urmo Võsa, Annique Claringbould, Harm-Jan Westra, Marc Jan Bonder, Patrick Deelen, Biao Zeng, Holger Kirsten, Ashis Saha, Roman Kreuzhuber, Silva Kasela, Natalia Pervjakova, Isabel Alvaes, Marie-Julie Fave, Mawusse Agbessi, Mark Christiansen, Rick Jansen, Ilkka Seppälä, Lin Tong, Alexander Teumer, Katharina Schramm, Gibran Hemani, Joost Verlouw, Hanieh Yaghootkar, Reyhan Sönmez, Andrew Brown, Viktorija Kukushkina, Anette Kalnapenkis, Sina Rüeger, Eleonora Porcu, Jaanika Kronberg-Guzman, Johannes Kettunen, Joseph Powell, Bernett Lee, Futao Zhang, Wibowo Arindrarto, Frank Beutner, BIOS Consortium, Harm Brugge, i2QTL Consortium, Julia Dmitreva, Mahmoud Elansary, Benjamin P. Fairfax, Michel Georges, Bastiaan T. Heijmans, Mika Kähönen, Yungil Kim, Julian C. Knight, Peter Kovacs, Knut Krohn, Shuang Li, Markus Loeffler, Urko M. Marigorta, Hailang Mei, Yukihide Momozawa, Martina Müller-Nurasyid, Matthias Nauck, Michel Nivard, Brenda Penninx, Jonathan Pritchard, Olli Raitakari, Olaf Rotzchke, Eline P. Slagboom, Coen D.A. Stehouwer, Michael Stumvoll, Patrick Sullivan, Peter A.C. ‘t Hoen, Joachim Thiery, Anke Tönjes, Jenny van Dongen, Maarten van Iterson, Jan Veldink, Uwe Völker, Cisca Wijmenga, Morris Swertz, Anand Andiappan, Grant W. Montgomery, Samuli Ripatti, Markus Perola, Zoltan Kutalik, Emmanouil Dermitzakis, Sven Bergmann, Timothy Frayling, Joyce van Meurs, Holger Prokisch, Habibul Ahsan, Brandon Pierce, Terho Lehtimäki, Dorret Boomsma, Bruce M. Psaty, Sina A. Gharib, Philip Awadalla, Lili Milani, Willem Ouwehand, Kate Downes, Oliver Stegle, Alexis Battle, Jian Yang, Peter M. Visscher, Markus Scholz, Gregory Gibson, Tõnu Esko, Lude Franke
bioRxiv 447367; doi: https://doi.org/10.1101/447367
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