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Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons

View ORCID ProfileRachel S. Lee, Marcelo G. Mattar, Nathan F. Parker, Ilana B. Witten, Nathaniel D. Daw
doi: https://doi.org/10.1101/447532
Rachel S. Lee
Princeton Neuroscience Institute, Department of Psychology, Princeton University, Princeton, NJ, USA 08550
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  • For correspondence: rachelstephlee@gmail.com
Marcelo G. Mattar
Princeton Neuroscience Institute, Department of Psychology, Princeton University, Princeton, NJ, USA 08550
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Nathan F. Parker
Princeton Neuroscience Institute, Department of Psychology, Princeton University, Princeton, NJ, USA 08550
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Ilana B. Witten
Princeton Neuroscience Institute, Department of Psychology, Princeton University, Princeton, NJ, USA 08550
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Nathaniel D. Daw
Princeton Neuroscience Institute, Department of Psychology, Princeton University, Princeton, NJ, USA 08550
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Abstract

Although midbrain dopamine (DA) neurons have been thought to primarily encode reward prediction error (RPE), recent studies have also found movement-related DAergic signals. For example, we recently reported that DA neurons in mice projecting to dorsomedial striatum are modulated by choices contralateral to the recording side. Here, we introduce, and ultimately reject, a candidate resolution for the puzzling RPE vs movement dichotomy, by showing how seemingly movement-related activity might be explained by an action-specific RPE. By considering both choice and RPE on a trial-by-trial basis, we find that DA signals are modulated by contralateral choice in a manner that is distinct from RPE, implying that choice encoding is better explained by movement direction. This fundamental separation between RPE and movement encoding may help shed light on the diversity of functions and dysfunctions of the DA system.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 04, 2019.
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Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons
Rachel S. Lee, Marcelo G. Mattar, Nathan F. Parker, Ilana B. Witten, Nathaniel D. Daw
bioRxiv 447532; doi: https://doi.org/10.1101/447532
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Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons
Rachel S. Lee, Marcelo G. Mattar, Nathan F. Parker, Ilana B. Witten, Nathaniel D. Daw
bioRxiv 447532; doi: https://doi.org/10.1101/447532

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