Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Receptor crosstalk improves concentration sensing of multiple ligands

Martín Carballo-Pacheco, Jonathan Desponds, Tatyana Gavrilchenko, Andreas Mayer, Roshan Prizak, Gautam Reddy, Ilya Nemenman, Thierry Mora
doi: https://doi.org/10.1101/448118
Martín Carballo-Pacheco
1School of Physics and Astronomy, University of Edinburgh, Edinburgh, EH9 3FD, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan Desponds
2Department of Physics, University of California San Diego, La Jolla, CA 92093, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tatyana Gavrilchenko
3Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andreas Mayer
4Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Roshan Prizak
5Institute of Science and Technology Austria, Am Campus 1, A-3400, Klosterneuburg, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gautam Reddy
2Department of Physics, University of California San Diego, La Jolla, CA 92093, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ilya Nemenman
6Department of Physics, Department of Biology, and Initiative in Theory andModeling of Living Systems, Emory University, Atlanta, GA 30322, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thierry Mora
7Laboratoire de physique statistique, CNRS, Sorbonne University, University Paris-Diderot and École normale supérieure (PSL University), 75005 Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Cells need to reliably sense external ligand concentrations to achieve various biological functions such as chemotaxis or signaling. The molecular recognition of ligands by surface receptors is degenerate in many systems leading to crosstalk between different receptors. Crosstalk is often thought of as a deviation from optimal specific recognition, as the binding of non-cognate ligands can interfere with the detection of the receptor’s cognate ligand, possibly leading to a false triggering of a downstream signaling pathway. Here we quantify the optimal precision of sensing the concentrations of multiple ligands by a collection of promiscuous receptors. We demonstrate that crosstalk can improve precision in concentration sensing and discrimination tasks. To achieve superior precision, the additional information about ligand concentrations contained in short binding events of the noncognate ligand should be exploited. We present a proofreading scheme to realize an approximate estimation of multiple ligand concentrations that reaches a precision close to the derived optimal bounds. Our results help rationalize the observed ubiquity of receptor crosstalk in molecular sensing.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted October 20, 2018.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Receptor crosstalk improves concentration sensing of multiple ligands
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Receptor crosstalk improves concentration sensing of multiple ligands
Martín Carballo-Pacheco, Jonathan Desponds, Tatyana Gavrilchenko, Andreas Mayer, Roshan Prizak, Gautam Reddy, Ilya Nemenman, Thierry Mora
bioRxiv 448118; doi: https://doi.org/10.1101/448118
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Receptor crosstalk improves concentration sensing of multiple ligands
Martín Carballo-Pacheco, Jonathan Desponds, Tatyana Gavrilchenko, Andreas Mayer, Roshan Prizak, Gautam Reddy, Ilya Nemenman, Thierry Mora
bioRxiv 448118; doi: https://doi.org/10.1101/448118

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Cell Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4847)
  • Biochemistry (10781)
  • Bioengineering (8035)
  • Bioinformatics (27263)
  • Biophysics (13967)
  • Cancer Biology (11115)
  • Cell Biology (16035)
  • Clinical Trials (138)
  • Developmental Biology (8773)
  • Ecology (13270)
  • Epidemiology (2067)
  • Evolutionary Biology (17346)
  • Genetics (11681)
  • Genomics (15905)
  • Immunology (11015)
  • Microbiology (26054)
  • Molecular Biology (10628)
  • Neuroscience (56486)
  • Paleontology (417)
  • Pathology (1729)
  • Pharmacology and Toxicology (3000)
  • Physiology (4539)
  • Plant Biology (9618)
  • Scientific Communication and Education (1613)
  • Synthetic Biology (2685)
  • Systems Biology (6970)
  • Zoology (1508)