Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Cell type-specific role of lamin-B1 and its inflammation-driven reduction in organ building and aging

Sibiao Yue, Xiaobin Zheng, Yixian Zheng
doi: https://doi.org/10.1101/448837
Sibiao Yue
1Department of Biology, Johns Hopkins University, Baltimore, MD 21218
2Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiaobin Zheng
2Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yixian Zheng
1Department of Biology, Johns Hopkins University, Baltimore, MD 21218
2Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Summary

Cellular architectural proteins often participate in organ development and maintenance. Although functional decay of some of these proteins during aging is known, the cell-type specific developmental role and the cause and consequence of their subsequent decay remain to be established especially in mammals. By studying lamins, the nuclear structural proteins, we demonstrate that lamin-B1 functions specifically in the thymic epithelial cells (TECs) for proper thymus organogenesis. An upregulation of proinflammatory cytokines in the intra-thymic myeloid immune cells during aging accompanies a gradual reduction of adult TEC lamins-B1. These cytokines cause adult TEC senescence and lamin-B1 reduction. We identify 17 adult TEC subsets and show that TEC lamin-B1 maintains the composition of these TECs. Lamin-B1 supports the expression of TEC genes needed for maintaining adult thymic architecture and function. Thus, structural proteins involved in organ building and maintenance can undergo inflammation-driven decay which can in turn contribute to age-associated organ degeneration.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted October 20, 2018.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Cell type-specific role of lamin-B1 and its inflammation-driven reduction in organ building and aging
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Cell type-specific role of lamin-B1 and its inflammation-driven reduction in organ building and aging
Sibiao Yue, Xiaobin Zheng, Yixian Zheng
bioRxiv 448837; doi: https://doi.org/10.1101/448837
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Cell type-specific role of lamin-B1 and its inflammation-driven reduction in organ building and aging
Sibiao Yue, Xiaobin Zheng, Yixian Zheng
bioRxiv 448837; doi: https://doi.org/10.1101/448837

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Immunology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4851)
  • Biochemistry (10792)
  • Bioengineering (8040)
  • Bioinformatics (27286)
  • Biophysics (13981)
  • Cancer Biology (11119)
  • Cell Biology (16049)
  • Clinical Trials (138)
  • Developmental Biology (8778)
  • Ecology (13279)
  • Epidemiology (2067)
  • Evolutionary Biology (17354)
  • Genetics (11687)
  • Genomics (15915)
  • Immunology (11028)
  • Microbiology (26070)
  • Molecular Biology (10637)
  • Neuroscience (56533)
  • Paleontology (417)
  • Pathology (1732)
  • Pharmacology and Toxicology (3003)
  • Physiology (4544)
  • Plant Biology (9628)
  • Scientific Communication and Education (1615)
  • Synthetic Biology (2685)
  • Systems Biology (6975)
  • Zoology (1508)