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Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank
Ioanna Tachmazidou, Konstantinos Hatzikotoulas, Lorraine Southam, Jorge Esparza-Gordillo, Valeriia Haberland, Jie Zheng, Toby Johnson, Mine Koprulu, Eleni Zengini, Julia Steinberg, Jeremy M Wilkinson, Sahir Bhatnagar, Joshua Hoffman, Natalie Buchan, Dániel Süveges, arcOGEN Consortium, Laura Yerges Armstrong, George Davey Smith, Tom R Gaunt, Robert A Scott, Linda C McCarthy, Eleftheria Zeggini
doi: https://doi.org/10.1101/453530
Ioanna Tachmazidou
1Target Sciences - R&D, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Konstantinos Hatzikotoulas
2Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK
3Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Lorraine Southam
2Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK
4Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
Jorge Esparza-Gordillo
1Target Sciences - R&D, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Valeriia Haberland
5MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Oakfield Grove Clifton, Bristol, BS8 2BN, UK
Jie Zheng
5MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Oakfield Grove Clifton, Bristol, BS8 2BN, UK
Toby Johnson
1Target Sciences - R&D, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Mine Koprulu
2Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK
6Department of Medical Genetics, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK
Eleni Zengini
7Department of Oncology and Metabolism, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
85th Psychiatric Department, Dromokaiteio Psychiatric Hospital, Haidari, Athens TK 12461, Greece
Julia Steinberg
2Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK
9Cancer Research Division, Cancer Council NSW, Woolloomooloo, New South Wales, Australia
Jeremy M Wilkinson
7Department of Oncology and Metabolism, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
Sahir Bhatnagar
10Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC H3A 1A2, Canada
Joshua Hoffman
11Target Sciences - R&D, GSK, 709 Swedeland Road, King of Prussia, PA 19406, US
Natalie Buchan
1Target Sciences - R&D, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Dániel Süveges
12European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
arcOGEN Consortium
13A list of arcOGEN Consortium members and affiliations appears in the Supplementary Note
Laura Yerges Armstrong
11Target Sciences - R&D, GSK, 709 Swedeland Road, King of Prussia, PA 19406, US
George Davey Smith
5MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Oakfield Grove Clifton, Bristol, BS8 2BN, UK
Tom R Gaunt
5MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Oakfield Grove Clifton, Bristol, BS8 2BN, UK
Robert A Scott
1Target Sciences - R&D, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Linda C McCarthy
1Target Sciences - R&D, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Eleftheria Zeggini
2Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK
3Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Article usage
Posted October 25, 2018.
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank
Ioanna Tachmazidou, Konstantinos Hatzikotoulas, Lorraine Southam, Jorge Esparza-Gordillo, Valeriia Haberland, Jie Zheng, Toby Johnson, Mine Koprulu, Eleni Zengini, Julia Steinberg, Jeremy M Wilkinson, Sahir Bhatnagar, Joshua Hoffman, Natalie Buchan, Dániel Süveges, arcOGEN Consortium, Laura Yerges Armstrong, George Davey Smith, Tom R Gaunt, Robert A Scott, Linda C McCarthy, Eleftheria Zeggini
bioRxiv 453530; doi: https://doi.org/10.1101/453530
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank
Ioanna Tachmazidou, Konstantinos Hatzikotoulas, Lorraine Southam, Jorge Esparza-Gordillo, Valeriia Haberland, Jie Zheng, Toby Johnson, Mine Koprulu, Eleni Zengini, Julia Steinberg, Jeremy M Wilkinson, Sahir Bhatnagar, Joshua Hoffman, Natalie Buchan, Dániel Süveges, arcOGEN Consortium, Laura Yerges Armstrong, George Davey Smith, Tom R Gaunt, Robert A Scott, Linda C McCarthy, Eleftheria Zeggini
bioRxiv 453530; doi: https://doi.org/10.1101/453530
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