Structure reveals mechanism of CRISPR RNA-guided nuclease recruitment and anti-CRISPR viral mimicry

MaryClare F. Rollins; Saikat Chowdhury; Joshua Carter; Sarah M. Golden; Heini M. Miettinen; Andrew Santiago-Frangos; Dominick Faith; C. Martin Lawrence; Gabriel C. Lander; Blake Wiedenheft

doi:10.1101/453720

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Structure reveals mechanism of CRISPR RNA-guided nuclease recruitment and anti-CRISPR viral mimicry

View ORCID ProfileMaryClare F. Rollins, View ORCID ProfileSaikat Chowdhury, Joshua Carter, Sarah M. Golden, Heini M. Miettinen, Andrew Santiago-Frangos, Dominick Faith, C. Martin Lawrence, View ORCID ProfileGabriel C. Lander, View ORCID ProfileBlake Wiedenheft

doi: https://doi.org/10.1101/453720

MaryClare F. Rollins

1Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA

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Saikat Chowdhury

3Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037, USA.

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Joshua Carter

1Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA

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Sarah M. Golden

1Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA

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Heini M. Miettinen

1Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA

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Andrew Santiago-Frangos

1Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA

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Dominick Faith

1Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA

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C. Martin Lawrence

2Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA

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Gabriel C. Lander

3Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037, USA.

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ORCID record for Gabriel C. Lander
For correspondence: glander@scripps.edu bwiedenheft@gmail.com

Blake Wiedenheft

1Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA

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For correspondence: glander@scripps.edu bwiedenheft@gmail.com

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Posted October 26, 2018.

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Structure reveals mechanism of CRISPR RNA-guided nuclease recruitment and anti-CRISPR viral mimicry

MaryClare F. Rollins, Saikat Chowdhury, Joshua Carter, Sarah M. Golden, Heini M. Miettinen, Andrew Santiago-Frangos, Dominick Faith, C. Martin Lawrence, Gabriel C. Lander, Blake Wiedenheft

bioRxiv 453720; doi: https://doi.org/10.1101/453720

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Structure reveals mechanism of CRISPR RNA-guided nuclease recruitment and anti-CRISPR viral mimicry

MaryClare F. Rollins, Saikat Chowdhury, Joshua Carter, Sarah M. Golden, Heini M. Miettinen, Andrew Santiago-Frangos, Dominick Faith, C. Martin Lawrence, Gabriel C. Lander, Blake Wiedenheft

bioRxiv 453720; doi: https://doi.org/10.1101/453720

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