Nuclease dead Cas9 is a programmable roadblock for DNA replication

Kelsey Whinn; Gurleen Kaur; Jacob S. Lewis; Grant Schauer; Stefan Müller; Slobodan Jergic; Hamish Maynard; Zhong Yan Gan; Matharishwan Naganbabu; Marcel P. Bruchez; Michael E. O’Donnell; Nicholas E. Dixon; Antoine M. van Oijen; Harshad Ghodke

doi:10.1101/455543

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Nuclease dead Cas9 is a programmable roadblock for DNA replication

Kelsey Whinn, Gurleen Kaur, Jacob S. Lewis, Grant Schauer, Stefan Müller, Slobodan Jergic, Hamish Maynard, Zhong Yan Gan, Matharishwan Naganbabu, Marcel P. Bruchez, Michael E. O’Donnell, Nicholas E. Dixon, Antoine M. van Oijen, Harshad Ghodke

doi: https://doi.org/10.1101/455543

Kelsey Whinn

1School of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong, New South Wales 2522, Australia

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Gurleen Kaur

1School of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong, New South Wales 2522, Australia

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Jacob S. Lewis

1School of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong, New South Wales 2522, Australia

2Illawarra Health and Medical Research Institute, Wollongong, New South Wales 2522, Australia

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Grant Schauer

3Howard Hughes Medical Institute, Rockefeller University, New York, NY 10065, USA

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Stefan Müller

1School of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong, New South Wales 2522, Australia

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Slobodan Jergic

1School of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong, New South Wales 2522, Australia

2Illawarra Health and Medical Research Institute, Wollongong, New South Wales 2522, Australia

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Hamish Maynard

1School of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong, New South Wales 2522, Australia

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Zhong Yan Gan

1School of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong, New South Wales 2522, Australia

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Matharishwan Naganbabu

4Department of Chemistry and Center for Nucleic Acids Science and Technology, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA

5Department of Biological Sciences and Molecular Biosensor and Imaging Center, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA

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Marcel P. Bruchez

4Department of Chemistry and Center for Nucleic Acids Science and Technology, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA

5Department of Biological Sciences and Molecular Biosensor and Imaging Center, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA

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Michael E. O’Donnell

3Howard Hughes Medical Institute, Rockefeller University, New York, NY 10065, USA

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Nicholas E. Dixon

1School of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong, New South Wales 2522, Australia

2Illawarra Health and Medical Research Institute, Wollongong, New South Wales 2522, Australia

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Antoine M. van Oijen

1School of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong, New South Wales 2522, Australia

2Illawarra Health and Medical Research Institute, Wollongong, New South Wales 2522, Australia

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Harshad Ghodke

1School of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong, New South Wales 2522, Australia

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