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Sub-millimeter fMRI reveals multiple topographical digit representations that form action maps in human motor cortex

View ORCID ProfileLaurentius Huber, Emily S. Finn, Daniel A. Handwerker, Marlene Bönstrup, Daniel Glen, Sriranga Kashyap, Dimo Ivanov, Natalia Petridou, Sean Marrett, Jozien Goense, Benedikt A. Poser, Peter A. Bandettini
doi: https://doi.org/10.1101/457002
Laurentius Huber
1NIMH, NIH, Bethesda, MD, USA
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  • ORCID record for Laurentius Huber
Emily S. Finn
1NIMH, NIH, Bethesda, MD, USA
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Daniel A. Handwerker
1NIMH, NIH, Bethesda, MD, USA
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Marlene Bönstrup
2NINDS, NIH, Bethesda, MD, USA
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Daniel Glen
1NIMH, NIH, Bethesda, MD, USA
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Sriranga Kashyap
3Maastricht Brain Imaging Centre, Maastricht University, Maastricht, The Netherlands
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Dimo Ivanov
3Maastricht Brain Imaging Centre, Maastricht University, Maastricht, The Netherlands
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Natalia Petridou
4University Medical Center Utrecht, Center for Image Sciences, Utrecht, The Netherlands
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Sean Marrett
1NIMH, NIH, Bethesda, MD, USA
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Jozien Goense
5School of Psychology, and Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK
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Benedikt A. Poser
3Maastricht Brain Imaging Centre, Maastricht University, Maastricht, The Netherlands
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Peter A. Bandettini
1NIMH, NIH, Bethesda, MD, USA
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Abstract

The human brain coordinates a wide variety of motor activities. On a large scale, the cortical motor system is topographically organized such that neighboring body parts are represented by neighboring brain areas. This homunculus-like somatotopic organization along the central sulcus has been observed using neuroimaging for large body parts such as the face, hands and feet. However, on a finer scale, invasive electrical stimulation studies show deviations from this somatotopic organization that suggest an organizing principle based on motor action. It has not been clear how the action-map organization principle of the motor cortex in the mesoscopic (sub-millimeter) regime integrates into a body map organization principle on a macroscopic scale (cm). Here we developed and applied advanced mesoscopic (sub-millimeter) fMRI and analysis methodology to non-invasively investigate the functional organization topography across columnar and laminar structures in humans. We find that individual fingers have multiple mirrored representations in the primary motor cortex depending on the movements they are involved in. We find that individual digits have cortical representations up to 3 mm apart from each other arranged in a column-like fashion. These representations are differentially engaged depending on whether the digits’ muscles are used for different motor actions such as flexion movements like grasping a ball or retraction movements like releasing a ball. This research provides a starting point for non-invasive investigation of mesoscale topography across layers and columns of the human cortex and bridges the gap between invasive electrophysiological investigations and large coverage non-invasive neuroimaging.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license.
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Posted October 30, 2018.
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Sub-millimeter fMRI reveals multiple topographical digit representations that form action maps in human motor cortex
Laurentius Huber, Emily S. Finn, Daniel A. Handwerker, Marlene Bönstrup, Daniel Glen, Sriranga Kashyap, Dimo Ivanov, Natalia Petridou, Sean Marrett, Jozien Goense, Benedikt A. Poser, Peter A. Bandettini
bioRxiv 457002; doi: https://doi.org/10.1101/457002
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Sub-millimeter fMRI reveals multiple topographical digit representations that form action maps in human motor cortex
Laurentius Huber, Emily S. Finn, Daniel A. Handwerker, Marlene Bönstrup, Daniel Glen, Sriranga Kashyap, Dimo Ivanov, Natalia Petridou, Sean Marrett, Jozien Goense, Benedikt A. Poser, Peter A. Bandettini
bioRxiv 457002; doi: https://doi.org/10.1101/457002

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