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Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases
View ORCID ProfileJason R. Burke, James J. La Clair, Ryan N. Philippe, Anna Pabis, Joseph M. Jez, George A. Cortina, Miriam Kaltenbach, Marianne E. Bowman, Gordon V. Louie, Katherine B. Woods, Andrew T. Nelson, Dan S. Tawfik, Shina C.L. Kamerlin, Joseph P. Noel
doi: https://doi.org/10.1101/457440
Jason R. Burke
†Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, CA 92037, United States
James J. La Clair
†Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, CA 92037, United States
Ryan N. Philippe
†Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, CA 92037, United States
Anna Pabis
‡Department of Chemistry - BMC, Uppsala University, BMC Box 576, S-751 23 Uppsala, Sweden
Joseph M. Jez
†Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, CA 92037, United States
George A. Cortina
§Department of Molecular Physiology and Biomedical Engineering, University of Virginia, Charlottesville, VA, United States
Miriam Kaltenbach
‖Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel
Marianne E. Bowman
†Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, CA 92037, United States
Gordon V. Louie
†Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, CA 92037, United States
Katherine B. Woods
†Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, CA 92037, United States
Andrew T. Nelson
¶Department of Chemistry, University of Texas at Austin, Austin, TX 78712, United States
Dan S. Tawfik
‖Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel
Shina C.L. Kamerlin
§Department of Molecular Physiology and Biomedical Engineering, University of Virginia, Charlottesville, VA, United States
Joseph P. Noel
†Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, CA 92037, United States
Article usage
Posted October 30, 2018.
Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases
Jason R. Burke, James J. La Clair, Ryan N. Philippe, Anna Pabis, Joseph M. Jez, George A. Cortina, Miriam Kaltenbach, Marianne E. Bowman, Gordon V. Louie, Katherine B. Woods, Andrew T. Nelson, Dan S. Tawfik, Shina C.L. Kamerlin, Joseph P. Noel
bioRxiv 457440; doi: https://doi.org/10.1101/457440
Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases
Jason R. Burke, James J. La Clair, Ryan N. Philippe, Anna Pabis, Joseph M. Jez, George A. Cortina, Miriam Kaltenbach, Marianne E. Bowman, Gordon V. Louie, Katherine B. Woods, Andrew T. Nelson, Dan S. Tawfik, Shina C.L. Kamerlin, Joseph P. Noel
bioRxiv 457440; doi: https://doi.org/10.1101/457440
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