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Linker histones regulate fine-scale chromatin organization and modulate developmental decisions in Arabidopsis

View ORCID ProfileKinga Rutowicz, View ORCID ProfileMaciej Lirski, Benoît Mermaz, View ORCID ProfileJasmin Schubert, Gianluca Teano, View ORCID ProfileImen Mestiri, Magdalena A. Kroteń, View ORCID ProfileTohnyui Ndinyanka Fabrice, Simon Fritz, View ORCID ProfileStefan Grob, View ORCID ProfileChristoph Ringli, Lusik Cherkezyan, View ORCID ProfileFredy Barneche, View ORCID ProfileAndrzej Jerzmanowski, View ORCID ProfileCélia Baroux
doi: https://doi.org/10.1101/458364
Kinga Rutowicz
1Institute of Plant and Microbial Biology, Zürich-Basel Plant Science Center, University of Zürich, Switzerland
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  • ORCID record for Kinga Rutowicz
Maciej Lirski
2Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Warsaw, Poland
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Benoît Mermaz
1Institute of Plant and Microbial Biology, Zürich-Basel Plant Science Center, University of Zürich, Switzerland
3Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole normale supérieure, CNRS, INSERM, PSL Research University, 75005 Paris, France
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Jasmin Schubert
1Institute of Plant and Microbial Biology, Zürich-Basel Plant Science Center, University of Zürich, Switzerland
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Gianluca Teano
4Département de Biologie, IBENS, Ecole Normale Supérieure, CNRS, INSERM, PSL Research University, 46 rue d’Ulm, F-75005, Paris, France
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Imen Mestiri
4Département de Biologie, IBENS, Ecole Normale Supérieure, CNRS, INSERM, PSL Research University, 46 rue d’Ulm, F-75005, Paris, France
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Magdalena A. Kroteń
5College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, 02-089 Warsaw, Poland
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Tohnyui Ndinyanka Fabrice
1Institute of Plant and Microbial Biology, Zürich-Basel Plant Science Center, University of Zürich, Switzerland
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Simon Fritz
1Institute of Plant and Microbial Biology, Zürich-Basel Plant Science Center, University of Zürich, Switzerland
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Stefan Grob
1Institute of Plant and Microbial Biology, Zürich-Basel Plant Science Center, University of Zürich, Switzerland
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Christoph Ringli
1Institute of Plant and Microbial Biology, Zürich-Basel Plant Science Center, University of Zürich, Switzerland
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Lusik Cherkezyan
6Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
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Fredy Barneche
4Département de Biologie, IBENS, Ecole Normale Supérieure, CNRS, INSERM, PSL Research University, 46 rue d’Ulm, F-75005, Paris, France
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Andrzej Jerzmanowski
2Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Warsaw, Poland
7Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106 Warsaw, Warsaw, Poland
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Célia Baroux
1Institute of Plant and Microbial Biology, Zürich-Basel Plant Science Center, University of Zürich, Switzerland
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Abstract

Chromatin in eukaryotes provides a tunable platform to control gene expression and convey an epigenetic memory throughout cell divisions. H1 linker histones are abundant components with an intrinsic potential in influencing chromatin structure and function. We detail the impact of H1 depletion in Arabidopsis on fine-scale chromatin organization, transcription and development. While required for chromocenter assembly, H1s are dispensable for transposable element (TE) silencing and peripheral positioning of heterochromatin. In euchromatin, H1 regulates nucleosome density, mobility, and regular distribution of nanoscale chromatin domains. While necessary to maintain epigenetic patterns, H1 only moderately affects transcription. Its depletion is associated with failures in transitional fate changes such as lateral root initiation, root hair production, stomata patterning but also flowering and dormancy regulation. Therefore, Arabidopsis H1 variants are chromatin architects mediating nano‐ and microscale levels-of-organization operating downstream of epigenetic and transcriptional establishment processes and contribute to epigenetic reorientations in developmental transitions.

Footnotes

  • kinga.rutowicz{at}uzh.ch, mlirski{at}poczta.onet.pl, mermazb{at}gmail.com, jasminschubert{at}msn.com, teano{at}biologie.ens.fr, mestiri{at}biologie.ens.fr, mkroten{at}gmail.com, nf.tohnyui{at}unibas.ch, simon.fritz{at}botinst.uzh.ch, stefan{at}grob.org, chringli{at}botinst.uzh.ch, barneche{at}biologie.ens.fr, andyj{at}ibb.waw.pl, cbaroux{at}botinst.uzh.ch, Lusik{at}u.northwestern.edu

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Posted October 31, 2018.
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Linker histones regulate fine-scale chromatin organization and modulate developmental decisions in Arabidopsis
Kinga Rutowicz, Maciej Lirski, Benoît Mermaz, Jasmin Schubert, Gianluca Teano, Imen Mestiri, Magdalena A. Kroteń, Tohnyui Ndinyanka Fabrice, Simon Fritz, Stefan Grob, Christoph Ringli, Lusik Cherkezyan, Fredy Barneche, Andrzej Jerzmanowski, Célia Baroux
bioRxiv 458364; doi: https://doi.org/10.1101/458364
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Linker histones regulate fine-scale chromatin organization and modulate developmental decisions in Arabidopsis
Kinga Rutowicz, Maciej Lirski, Benoît Mermaz, Jasmin Schubert, Gianluca Teano, Imen Mestiri, Magdalena A. Kroteń, Tohnyui Ndinyanka Fabrice, Simon Fritz, Stefan Grob, Christoph Ringli, Lusik Cherkezyan, Fredy Barneche, Andrzej Jerzmanowski, Célia Baroux
bioRxiv 458364; doi: https://doi.org/10.1101/458364

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