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Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice

Matthew Simon, Michael Van Meter, Julia Ablaeva, Zhonghe Ke, Raul S. Gonzalez, Taketo Taguchi, Marco De Cecco, Katerina I. Leonova, Valeria Kogan, Stephen L. Helfand, Nicola Neretti, Asael Roichman, Haim Y. Cohen, Marina Antoch, Andrei Gudkov, John M. Sedivy, Andrei Seluanov, Vera Gorbunova
doi: https://doi.org/10.1101/460808
Matthew Simon
1Department of Biology, University of Rochester, Rochester, New York 14627, USA
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Michael Van Meter
1Department of Biology, University of Rochester, Rochester, New York 14627, USA
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Julia Ablaeva
1Department of Biology, University of Rochester, Rochester, New York 14627, USA
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Zhonghe Ke
1Department of Biology, University of Rochester, Rochester, New York 14627, USA
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Raul S. Gonzalez
2Department of Pathology, University of Rochester Medical Center, Rochester, New York 14627, USA
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Taketo Taguchi
1Department of Biology, University of Rochester, Rochester, New York 14627, USA
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Marco De Cecco
4Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
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Katerina I. Leonova
3Department of Cell Stress Biology, CGP 3310, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
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Valeria Kogan
3Department of Cell Stress Biology, CGP 3310, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
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Stephen L. Helfand
4Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
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Nicola Neretti
4Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
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Asael Roichman
5Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
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Haim Y. Cohen
5Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
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Marina Antoch
3Department of Cell Stress Biology, CGP 3310, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
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Andrei Gudkov
3Department of Cell Stress Biology, CGP 3310, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
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John M. Sedivy
4Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
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Andrei Seluanov
1Department of Biology, University of Rochester, Rochester, New York 14627, USA
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  • For correspondence: vera.gorbunova@rochester.edu andrei.seluanov@rochester.edu
Vera Gorbunova
1Department of Biology, University of Rochester, Rochester, New York 14627, USA
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  • For correspondence: vera.gorbunova@rochester.edu andrei.seluanov@rochester.edu
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Article Information

doi 
https://doi.org/10.1101/460808
History 
  • November 4, 2018.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

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Posted November 04, 2018.
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Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice
Matthew Simon, Michael Van Meter, Julia Ablaeva, Zhonghe Ke, Raul S. Gonzalez, Taketo Taguchi, Marco De Cecco, Katerina I. Leonova, Valeria Kogan, Stephen L. Helfand, Nicola Neretti, Asael Roichman, Haim Y. Cohen, Marina Antoch, Andrei Gudkov, John M. Sedivy, Andrei Seluanov, Vera Gorbunova
bioRxiv 460808; doi: https://doi.org/10.1101/460808
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Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice
Matthew Simon, Michael Van Meter, Julia Ablaeva, Zhonghe Ke, Raul S. Gonzalez, Taketo Taguchi, Marco De Cecco, Katerina I. Leonova, Valeria Kogan, Stephen L. Helfand, Nicola Neretti, Asael Roichman, Haim Y. Cohen, Marina Antoch, Andrei Gudkov, John M. Sedivy, Andrei Seluanov, Vera Gorbunova
bioRxiv 460808; doi: https://doi.org/10.1101/460808

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