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Magnetoelectric materials for miniature, wireless neural stimulation at therapeutic frequencies

Amanda Wickens, Benjamin Avants, Nishant Verma, Eric Lewis, Joshua C. Chen, Ariel K. Feldman, Shayok Dutta, Joshua Chu, John O’Malley, Michael Beierlein, Caleb Kemere, Jacob T. Robinson
doi: https://doi.org/10.1101/461855
Amanda Wickens
Applied Physics Program, Rice University, Houston, Texas, USADepartment of Electrical and Computer Engineering, Rice University, Houston, Texas, USA
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Benjamin Avants
Department of Electrical and Computer Engineering, Rice University, Houston, Texas, USA
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Nishant Verma
Department of Bioengineering, Rice University, Houston, Texas, USA
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Eric Lewis
Department of Electrical and Computer Engineering, Rice University, Houston, Texas, USA
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Joshua C. Chen
Department of Bioengineering, Rice University, Houston, Texas, USA
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Ariel K. Feldman
Department of Computer Science, Rice University, Houston, Texas, USADepartment of Cognitive Science, Rice University, Houston, Texas, USA
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Shayok Dutta
Department of Electrical and Computer Engineering, Rice University, Houston, Texas, USA
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Joshua Chu
Department of Electrical and Computer Engineering, Rice University, Houston, Texas, USA
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John O’Malley
Department of Neurobiology and Anatomy, McGovern Medical School at UTHealth, Houston, Texas, USA
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Michael Beierlein
Department of Neurobiology and Anatomy, McGovern Medical School at UTHealth, Houston, Texas, USA
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Caleb Kemere
Department of Electrical and Computer Engineering, Rice University, Houston, Texas, USADepartment of Bioengineering, Rice University, Houston, Texas, USA
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Jacob T. Robinson
Applied Physics Program, Rice University, Houston, Texas, USADepartment of Electrical and Computer Engineering, Rice University, Houston, Texas, USADepartment of Bioengineering, Rice University, Houston, Texas, USADepartment of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
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Abstract

A fundamental challenge for bioelectronics is to deliver power to miniature devices inside the body. Wires are common failure points and limit device placement. Wireless power by electromagnetic or ultrasound waves must overcome absorption by the body and impedance mismatches between air, bone, and tissue. Magnetic fields, on the other hand, suffer little absorption by the body or differences in impedance at interfaces between air, bone, and tissue. These advantages have led to magnetically-powered stimulators based on induction or magnetothermal effects. However, fundamental limitations in these power transfer technologies have prevented miniature magnetically-powered stimulators from applications in many therapies and disease models because they do not operate in clinical “high-frequency” ranges above 20 Hz. Here we show that magnetoelectric materials – applied for the first time in bioelectronics devices – enable miniature magnetically-powered neural stimulators that operate at clinically relevant high-frequencies. As an example, we show that ME neural stimulators can effectively treat the symptoms of a Parkinson’s disease model in a freely behaving rodent. We also show that ME-powered devices can be miniaturized to sizes smaller than a grain of rice while maintaining effective stimulation voltages. These results suggest that ME materials are an excellent candidate for wireless power delivery that will enable miniature neural stimulators in both clinical and research applications.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted November 05, 2018.
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Magnetoelectric materials for miniature, wireless neural stimulation at therapeutic frequencies
Amanda Wickens, Benjamin Avants, Nishant Verma, Eric Lewis, Joshua C. Chen, Ariel K. Feldman, Shayok Dutta, Joshua Chu, John O’Malley, Michael Beierlein, Caleb Kemere, Jacob T. Robinson
bioRxiv 461855; doi: https://doi.org/10.1101/461855
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Magnetoelectric materials for miniature, wireless neural stimulation at therapeutic frequencies
Amanda Wickens, Benjamin Avants, Nishant Verma, Eric Lewis, Joshua C. Chen, Ariel K. Feldman, Shayok Dutta, Joshua Chu, John O’Malley, Michael Beierlein, Caleb Kemere, Jacob T. Robinson
bioRxiv 461855; doi: https://doi.org/10.1101/461855

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