Rational Discovery of Dual-Action Multi-Target Kinase Inhibitor for Precision Anti-Cancer Therapy Using Structural Systems Pharmacology

Hansaim Lim; Di He; Yue Qiu; Patrycja Krawczuk; Xiaoru Sun; Lei Xie

doi:10.1101/465054

Article Information

doi

https://doi.org/10.1101/465054

History

November 7, 2018.

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

Hansaim Lim1,#,
Di He2,#,
Yue Qiu3,#,
Patrycja Krawczuk4,
Xiaoru Sun4,5 and
Lei Xie1,2,3,4,∗

¹Ph.D. Program in Biochemistry, The Graduate Center, The City University of New York
²Ph.D. Program in Computer Science, The Graduate Center, The City University of New York
³Ph.D. Program in Biology, The Graduate Center, The City University of New York
⁴Department of Computer Science, Hunter College, The City University of New York
⁵Department of Biostatistics, School of Public Heath, Shandong University

↵∗Corresponding author: Lei Xie, Ph.D. Program in Biology, Biochemistry, & Computer Science, and Department of Computer Science, Hunter College, The City University of New York, 695 Park Avenue, New York City, NY 10065, U.S.A., Phone: (212)396-6550, Fax: (212)772-5219, Email: lei.xie{at}hunter.cuny.edu