Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Results dissemination from clinical trials conducted at German university medical centres was delayed and incomplete

Susanne Wieschowski, Nico Riedel, Katharina Wollmann, Hannes Kahrass, Stephanie Müller-Ohlraun, Christopher Schürmann, Sean Kelley, Ute Kszuk, Bob Siegerink, Ulrich Dirnagl, Jörg Meerpohl, View ORCID ProfileDaniel Strech
doi: https://doi.org/10.1101/467746
Susanne Wieschowski
1Institute for Ethics, History, and Philosophy of Medicine, Hannover Medical School, Hannover, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nico Riedel
2QUEST Center for Transforming Biomedical Research, Berlin Institute of Health, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katharina Wollmann
3Institute for Evidence in Medicine (for Cochrane Germany Foundation), Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany
6Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hannes Kahrass
1Institute for Ethics, History, and Philosophy of Medicine, Hannover Medical School, Hannover, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stephanie Müller-Ohlraun
2QUEST Center for Transforming Biomedical Research, Berlin Institute of Health, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher Schürmann
1Institute for Ethics, History, and Philosophy of Medicine, Hannover Medical School, Hannover, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sean Kelley
4Charité Universitätsmedizin Berlin, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ute Kszuk
5Cochrane Germany Foundation, Freiburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bob Siegerink
6Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ulrich Dirnagl
2QUEST Center for Transforming Biomedical Research, Berlin Institute of Health, Berlin, Germany
4Charité Universitätsmedizin Berlin, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jörg Meerpohl
3Institute for Evidence in Medicine (for Cochrane Germany Foundation), Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel Strech
1Institute for Ethics, History, and Philosophy of Medicine, Hannover Medical School, Hannover, Germany
2QUEST Center for Transforming Biomedical Research, Berlin Institute of Health, Berlin, Germany
4Charité Universitätsmedizin Berlin, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Daniel Strech
  • For correspondence: daniel.strech@charite.de
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Objective Timely and comprehensive reporting of clinical trial results build the backbone of evidence-based medicine and responsible research. The proportion of timely disseminated trial results can inform alternative national and international benchmarking of university medical centers (UMCs).

Study Design and Setting For all German UMCs we tracked all registered trials completed between 2009 and 2013. The results and an interactive website benchmark German UMCs regarding their performance in results dissemination.

Results We identified and tracked 2,132 clinical trials. For 1,509 trials, one of the German UMCs took the academic lead. Of these 1,509 “lead trials”, 39% published their results (mostly via journal publications) in a timely manner (<24 months after completion). More than six years after study completion, 26% of all eligible lead trials still had not disseminated results.

Conclusion Despite substantial attention from many stakeholders to the topic, there is still a strong delay or even absence of results dissemination for many trials. German UMCs have several opportunities to improve this situation. Further research should evaluate whether and how a transparent benchmarking of UMC performance in results dissemination helps to increase value and reduce waste in medical research.

Footnotes

  • Title and abstract have been changed according to journal requirements. Methods and results have been adapted to improve clarity.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted June 11, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Results dissemination from clinical trials conducted at German university medical centres was delayed and incomplete
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Results dissemination from clinical trials conducted at German university medical centres was delayed and incomplete
Susanne Wieschowski, Nico Riedel, Katharina Wollmann, Hannes Kahrass, Stephanie Müller-Ohlraun, Christopher Schürmann, Sean Kelley, Ute Kszuk, Bob Siegerink, Ulrich Dirnagl, Jörg Meerpohl, Daniel Strech
bioRxiv 467746; doi: https://doi.org/10.1101/467746
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Results dissemination from clinical trials conducted at German university medical centres was delayed and incomplete
Susanne Wieschowski, Nico Riedel, Katharina Wollmann, Hannes Kahrass, Stephanie Müller-Ohlraun, Christopher Schürmann, Sean Kelley, Ute Kszuk, Bob Siegerink, Ulrich Dirnagl, Jörg Meerpohl, Daniel Strech
bioRxiv 467746; doi: https://doi.org/10.1101/467746

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Scientific Communication and Education
Subject Areas
All Articles
  • Animal Behavior and Cognition (4667)
  • Biochemistry (10332)
  • Bioengineering (7653)
  • Bioinformatics (26277)
  • Biophysics (13497)
  • Cancer Biology (10663)
  • Cell Biology (15389)
  • Clinical Trials (138)
  • Developmental Biology (8480)
  • Ecology (12800)
  • Epidemiology (2067)
  • Evolutionary Biology (16817)
  • Genetics (11378)
  • Genomics (15451)
  • Immunology (10591)
  • Microbiology (25141)
  • Molecular Biology (10187)
  • Neuroscience (54317)
  • Paleontology (399)
  • Pathology (1663)
  • Pharmacology and Toxicology (2889)
  • Physiology (4331)
  • Plant Biology (9223)
  • Scientific Communication and Education (1585)
  • Synthetic Biology (2551)
  • Systems Biology (6769)
  • Zoology (1459)