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WUSCHEL acts as a rheostat on the auxin pathway to maintain apical stem cells in Arabidopsis

Yanfei Ma, View ORCID ProfileAndrej Miotk, Zoran Sutikovic, View ORCID ProfileAnna Medzihradszky, Christian Wenzl, View ORCID ProfileOlga Ermakova, View ORCID ProfileChristophe Gaillochet, View ORCID ProfileJoachim Forner, View ORCID ProfileGoedze Utan, View ORCID ProfileKlaus Brackmann, Carlos S. Galvan-Ampudia, View ORCID ProfileTeva Vernoux, View ORCID ProfileThomas Greb, View ORCID ProfileJan U. Lohmann
doi: https://doi.org/10.1101/468421
Yanfei Ma
Heidelberg University;
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Andrej Miotk
Heidelberg University;
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Zoran Sutikovic
Heidelberg University;
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Anna Medzihradszky
Heidelberg University;
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Christian Wenzl
Heidelberg University;
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Olga Ermakova
Heidelberg University;
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Christophe Gaillochet
Heidelberg University;
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Joachim Forner
Heidelberg University;
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Goedze Utan
Heidelberg University;
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Klaus Brackmann
Gregor Mendel Institut;
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Carlos S. Galvan-Ampudia
ENS Lyon
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Teva Vernoux
ENS Lyon
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Thomas Greb
Heidelberg University;
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Jan U. Lohmann
Heidelberg University;
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  • For correspondence: jlohmann@meristemania.org
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Abstract

To maintain the balance between long-term stem cell self-renewal and differentiation, dynamic signals need to be translated into spatially precise and temporally stable gene expression states. In the apical plant stem cell system, local accumulation of the small, highly mobile phytohormone auxin triggers differentiation while at the same time, pluripotent stem cells are maintained throughout the entire life-cycle. We find that stem cells are resistant to auxin mediated differentiation, but require low levels of signaling for their maintenance. We demonstrate that the WUSCHEL transcription factor confers this behavior by rheostatically controlling the auxin signaling and response pathway. Finally, we show that WUSCHEL acts via regulation of histone acetylation at target loci, including those with functions in the auxin pathway. Our results reveal an important mechanism that allows cells to differentially translate a potent and highly dynamic developmental signal into stable cell behavior with high spatial precision and temporal robustness.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 10, 2019.
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WUSCHEL acts as a rheostat on the auxin pathway to maintain apical stem cells in Arabidopsis
Yanfei Ma, Andrej Miotk, Zoran Sutikovic, Anna Medzihradszky, Christian Wenzl, Olga Ermakova, Christophe Gaillochet, Joachim Forner, Goedze Utan, Klaus Brackmann, Carlos S. Galvan-Ampudia, Teva Vernoux, Thomas Greb, Jan U. Lohmann
bioRxiv 468421; doi: https://doi.org/10.1101/468421
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WUSCHEL acts as a rheostat on the auxin pathway to maintain apical stem cells in Arabidopsis
Yanfei Ma, Andrej Miotk, Zoran Sutikovic, Anna Medzihradszky, Christian Wenzl, Olga Ermakova, Christophe Gaillochet, Joachim Forner, Goedze Utan, Klaus Brackmann, Carlos S. Galvan-Ampudia, Teva Vernoux, Thomas Greb, Jan U. Lohmann
bioRxiv 468421; doi: https://doi.org/10.1101/468421

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