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CD8+ lymphocytes modulate Zika virus dynamics and tissue dissemination and orchestrate antiviral immunity

Blake Schouest, Marissa Fahlberg, Elizabeth A. Scheef, Matthew J. Ward, Kyra Headrick, Dawn M. Szeltner, Robert V. Blair, Margaret H. Gilbert, Lara A. Doyle-Meyers, Victoria W. Danner, Myrna C. Bonaldo, Dawn M. Wesson, Antonito T. Panganiban, Nicholas J. Maness
doi: https://doi.org/10.1101/475418
Blake Schouest
1Biomedical Sciences Training Program, Tulane University School of Medicine, New Orleans, LA, USA
2Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA
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Marissa Fahlberg
3Division of Immunology, Tulane National Primate Research Center, Covington, LA, USA
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Elizabeth A. Scheef
2Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA
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Matthew J. Ward
4School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA
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Kyra Headrick
4School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA
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Dawn M. Szeltner
2Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA
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Robert V. Blair
5Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA
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Margaret H. Gilbert
6Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA, USA
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Lara A. Doyle-Meyers
6Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA, USA
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Victoria W. Danner
6Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA, USA
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Myrna C. Bonaldo
7Laboratório de Biologia Molecular de Flavivírus, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil
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Dawn M. Wesson
4School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA
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Antonito T. Panganiban
2Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA
8Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA
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Nicholas J. Maness
2Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA
8Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA
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  • For correspondence: nmaness@tulane.edu
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Article Information

doi 
https://doi.org/10.1101/475418
History 
  • July 11, 2019.

Article Versions

  • Version 1 (November 20, 2018 - 14:22).
  • Version 2 (April 15, 2019 - 14:19).
  • You are viewing Version 3, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Blake Schouest1,2,
  2. Marissa Fahlberg3,
  3. Elizabeth A. Scheef2,
  4. Matthew J. Ward4,
  5. Kyra Headrick4,
  6. Dawn M. Szeltner2,
  7. Robert V. Blair5,
  8. Margaret H. Gilbert6,
  9. Lara A. Doyle-Meyers6,
  10. Victoria W. Danner6,
  11. Myrna C. Bonaldo7,
  12. Dawn M. Wesson4,
  13. Antonito T. Panganiban2,8 and
  14. Nicholas J. Maness2,8,*
  1. 1Biomedical Sciences Training Program, Tulane University School of Medicine, New Orleans, LA, USA
  2. 2Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA
  3. 3Division of Immunology, Tulane National Primate Research Center, Covington, LA, USA
  4. 4School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA
  5. 5Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA
  6. 6Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA, USA
  7. 7Laboratório de Biologia Molecular de Flavivírus, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil
  8. 8Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA
  1. ↵*Corresponding author, Nicholas J Maness, nmaness{at}tulane.edu
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Posted July 11, 2019.
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CD8+ lymphocytes modulate Zika virus dynamics and tissue dissemination and orchestrate antiviral immunity
Blake Schouest, Marissa Fahlberg, Elizabeth A. Scheef, Matthew J. Ward, Kyra Headrick, Dawn M. Szeltner, Robert V. Blair, Margaret H. Gilbert, Lara A. Doyle-Meyers, Victoria W. Danner, Myrna C. Bonaldo, Dawn M. Wesson, Antonito T. Panganiban, Nicholas J. Maness
bioRxiv 475418; doi: https://doi.org/10.1101/475418
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CD8+ lymphocytes modulate Zika virus dynamics and tissue dissemination and orchestrate antiviral immunity
Blake Schouest, Marissa Fahlberg, Elizabeth A. Scheef, Matthew J. Ward, Kyra Headrick, Dawn M. Szeltner, Robert V. Blair, Margaret H. Gilbert, Lara A. Doyle-Meyers, Victoria W. Danner, Myrna C. Bonaldo, Dawn M. Wesson, Antonito T. Panganiban, Nicholas J. Maness
bioRxiv 475418; doi: https://doi.org/10.1101/475418

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