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The impact of bilateral ongoing activity on evoked responses in mouse cortex

Daisuke Shimaoka, View ORCID ProfileNicholas A Steinmetz, View ORCID ProfileKenneth D Harris, Matteo Carandini
doi: https://doi.org/10.1101/476333
Daisuke Shimaoka
1UCL Institute of Ophthalmology, University College London, Gower Street, London WC1E 6AE
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  • For correspondence: d.shimaoka@ucl.ac.uk
Nicholas A Steinmetz
1UCL Institute of Ophthalmology, University College London, Gower Street, London WC1E 6AE
2UCL Institute of Neurology, University College London, Gower Street, London WC1E 6AE
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  • ORCID record for Nicholas A Steinmetz
Kenneth D Harris
2UCL Institute of Neurology, University College London, Gower Street, London WC1E 6AE
3Department of Neuroscience, University College London, Gower Street, London WC1E 6AE
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Matteo Carandini
1UCL Institute of Ophthalmology, University College London, Gower Street, London WC1E 6AE
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Abstract

The ongoing activity of the left and right cortical hemispheres shows strong bilateral fluctuations. Here we show that these fluctuations are largely responsible for the variability observed in cortical responses to sensory stimuli. Using widefield imaging of voltage and calcium signals, we measured activity in the cortex of mice performing a visual detection task. Bilateral fluctuations invested all areas, particularly those closest to the midline. Activity was less bilateral in the monocular region of primary visual cortex and, especially during task engagement, in secondary motor cortex. Ongoing bilateral fluctuations dominated unilateral visual responses, and interacted additively with them, explaining much of the variance in trial-by-trial activity. Even though these fluctuations occurred in regions necessary for the task, they did not impact detection behavior. We conclude that bilateral ongoing activity continues during sensory stimulation and has a powerful additive impact on sensory processing.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted November 22, 2018.
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The impact of bilateral ongoing activity on evoked responses in mouse cortex
Daisuke Shimaoka, Nicholas A Steinmetz, Kenneth D Harris, Matteo Carandini
bioRxiv 476333; doi: https://doi.org/10.1101/476333
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The impact of bilateral ongoing activity on evoked responses in mouse cortex
Daisuke Shimaoka, Nicholas A Steinmetz, Kenneth D Harris, Matteo Carandini
bioRxiv 476333; doi: https://doi.org/10.1101/476333

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