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Limits of chromosome compaction by loop-extruding motors

View ORCID ProfileEdward J. Banigan, View ORCID ProfileLeonid A. Mirny
doi: https://doi.org/10.1101/476424
Edward J. Banigan
1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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Leonid A. Mirny
1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
2Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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Abstract

During mitosis, human chromosomes are linearly compacted ~ 1000-fold by loop-extruding motors. Recent experiments have shown that condensins extrude DNA loops, but in a “one-sided” manner. We explore whether one-sided extrusion can compact chromosomes by developing a mean-field model for polymer compaction by motors that actively extrude loops and turnover. The model establishes an upper bound of only ~ 10-fold for compaction by one-sided extrusion. Thus, it cannot be the sole mechanism of chromosome compaction. However, other, effectively two-sided mechanisms can achieve sufficient compaction.

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Posted November 21, 2018.
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Limits of chromosome compaction by loop-extruding motors
Edward J. Banigan, Leonid A. Mirny
bioRxiv 476424; doi: https://doi.org/10.1101/476424
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Limits of chromosome compaction by loop-extruding motors
Edward J. Banigan, Leonid A. Mirny
bioRxiv 476424; doi: https://doi.org/10.1101/476424

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