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Carbs versus fat: does it really matter for maintaining lost weight?

View ORCID ProfileKevin D. Hall, Juen Guo
doi: https://doi.org/10.1101/476655
Kevin D. Hall
National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892
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  • ORCID record for Kevin D. Hall
Juen Guo
National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892
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Key messages

  • The latest battle in the perpetual diet wars claimed that low carbohydrate diets offer a metabolic advantage to burn more calories and thereby help patients maintain lost weight.

  • However, analyzing the data according to the original pre-registered statistical plan resulted in no statistically significant effects of diet composition on energy expenditure.

  • The large reported diet effect on expenditure calculated using the revised analysis plan depended on data from subjects with excessive amounts of unaccounted energy. Adjusting the data to be commensurate with energy conservation resulted in a diet effect that was less than half the value reported in the BMJ paper.

  • The measured daily average CO2 production rates were not significantly different between the diets and the reported expenditure differences were due to inaccurate calculations based on false assumptions about diet adherence.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license.
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Posted January 24, 2019.
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Carbs versus fat: does it really matter for maintaining lost weight?
Kevin D. Hall, Juen Guo
bioRxiv 476655; doi: https://doi.org/10.1101/476655
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Carbs versus fat: does it really matter for maintaining lost weight?
Kevin D. Hall, Juen Guo
bioRxiv 476655; doi: https://doi.org/10.1101/476655

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