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Confirmatory Results

Two linked loci under mutation-selection balance and Muller’s ratchet

Ksenia A. Khudyakova, Tatiana Yu. Neretina, Alexey S. Kondrashov
doi: https://doi.org/10.1101/477489
Ksenia A. Khudyakova
1Laboratory of Evolutionary Genomics, A.N. Belozersky Institute of Physico-Chemical Biology of Lomonosov Moscow State University, Moscow, 119992, Russia
2Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119234, Russia
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Tatiana Yu. Neretina
4Department of Mechanics and Mathematics, Lomonosov Moscow State University, Moscow, 119991, Russia
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Alexey S. Kondrashov
1Laboratory of Evolutionary Genomics, A.N. Belozersky Institute of Physico-Chemical Biology of Lomonosov Moscow State University, Moscow, 119992, Russia
3Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, 48109, USA
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Abstract

We report the complete analysis of a deterministic model of deleterious mutations and negative selection against them at two haploid loci without recombination. As long as mutation is a weaker force than selection, mutant alleles remain rare at the only stable equilibrium, and otherwise, a variety of dynamics are possible. If the mutation-free genotype is absent, generally the only stable equilibrium is the one that corresponds to fixation of the mutant allele at the locus where it is less deleterious. This result suggests that fixation of a deleterious allele that follows a click of the Muller’s ratchet is governed by natural selection, instead of random drift.

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  • Declarations of interest: none

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Posted November 24, 2018.
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Two linked loci under mutation-selection balance and Muller’s ratchet
Ksenia A. Khudyakova, Tatiana Yu. Neretina, Alexey S. Kondrashov
bioRxiv 477489; doi: https://doi.org/10.1101/477489
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Two linked loci under mutation-selection balance and Muller’s ratchet
Ksenia A. Khudyakova, Tatiana Yu. Neretina, Alexey S. Kondrashov
bioRxiv 477489; doi: https://doi.org/10.1101/477489

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