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Long-term balancing selection drives evolution of immunity genes in Capsella

Daniel Koenig, Jörg Hagmann, View ORCID ProfileRachel Li, Felix Bemm, Tanja Slotte, Barbara Neuffer, View ORCID ProfileStephen I. Wright, View ORCID ProfileDetlef Weigel
doi: https://doi.org/10.1101/477612
Daniel Koenig
1Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany
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  • For correspondence: weigel@tue.mpg.de dkoenig@ucr.edu
Jörg Hagmann
1Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany
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Rachel Li
1Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany
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Felix Bemm
1Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany
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Tanja Slotte
2Department of Ecology, Environment, and Plant Sciences, Stockholm University, Stockholm, Sweden
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Barbara Neuffer
3Department of Biology, University of Osnabrück, Osnabrück, Germany
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Stephen I. Wright
3Department of Biology, University of Osnabrück, Osnabrück, Germany
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Detlef Weigel
1Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany
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  • ORCID record for Detlef Weigel
  • For correspondence: weigel@tue.mpg.de dkoenig@ucr.edu
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ABSTRACT

Genetic drift is expected to remove polymorphism from populations over long periods of time, with the rate of polymorphism loss being accelerated when species experience strong reductions in population size. Adaptive forces that maintain genetic variation in populations, or balancing selection, might counteract this process. To understand the extent to which natural selection can drive the retention of genetic diversity, we document genomic variability after two parallel species-wide bottlenecks in the genus Capsella. We find that ancestral variation preferentially persists at immunity related loci, and that the same collection of alleles has been maintained in different lineages that have been separated for several million years. Our data point to long term balancing selection as an important factor shaping the genetics of immune systems in plants and as the predominant driver of genomic variability after a population bottleneck.

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Posted November 26, 2018.
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Long-term balancing selection drives evolution of immunity genes in Capsella
Daniel Koenig, Jörg Hagmann, Rachel Li, Felix Bemm, Tanja Slotte, Barbara Neuffer, Stephen I. Wright, Detlef Weigel
bioRxiv 477612; doi: https://doi.org/10.1101/477612
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Long-term balancing selection drives evolution of immunity genes in Capsella
Daniel Koenig, Jörg Hagmann, Rachel Li, Felix Bemm, Tanja Slotte, Barbara Neuffer, Stephen I. Wright, Detlef Weigel
bioRxiv 477612; doi: https://doi.org/10.1101/477612

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