Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Vitamin D status and risk of incident tuberculosis disease: a systematic review and individual participant data meta-analysis

Omowunmi Aibana, Chuan-Chin Huang, Said Aboud, Alberto Arnedo-Pena, Mercedes C. Becerra, Juan Bautista Bellido-Blasco, Ramesh Bhosale, Roger Calderon, Silvia Chiang, Carmen Contreras, Ganmaa Davaasambuu, Wafaie W. Fawzi, Molly F. Franke, Jerome T. Galea, Daniel Garcia-Ferrer, Maria Gil-Fortuño, Barbará Gomila-Sard, Amita Gupta, Nikhil Gupte, Rabia Hussain, Jesus Iborra-Millet, Najeeha T. Iqbal, Jose Vicente Juan-Cerdán, Aarti Kinikar, Leonid Lecca, Vidya Mave, Noemi Meseguer-Ferrer, Grace Montepiedra, Ferdinand M. Mugusi, Olumuyiwa A. Owolabi, Julie Parsonnet, Freddy Roach-Poblete, Maria Angeles Romeu-García, Stephen A. Spector, Christopher R. Sudfeld, Mark W. Tenforde, Toyin O. Togun, Rosa Yataco, Zibiao Zhang, Megan B. Murray
doi: https://doi.org/10.1101/481739
Omowunmi Aibana
Department of Internal Medicine, McGovern Medical School at the University of Texas Health Science Center, 6431 Fannin Street, MSB 1.122, Houston, Texas 77030, USA (O Aibana MD);
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chuan-Chin Huang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Said Aboud
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alberto Arnedo-Pena
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mercedes C. Becerra
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Juan Bautista Bellido-Blasco
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ramesh Bhosale
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Roger Calderon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Silvia Chiang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carmen Contreras
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ganmaa Davaasambuu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wafaie W. Fawzi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Molly F. Franke
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jerome T. Galea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel Garcia-Ferrer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria Gil-Fortuño
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Barbará Gomila-Sard
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amita Gupta
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nikhil Gupte
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rabia Hussain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jesus Iborra-Millet
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Najeeha T. Iqbal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jose Vicente Juan-Cerdán
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aarti Kinikar
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leonid Lecca
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vidya Mave
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Noemi Meseguer-Ferrer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Grace Montepiedra
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ferdinand M. Mugusi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Olumuyiwa A. Owolabi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julie Parsonnet
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Freddy Roach-Poblete
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria Angeles Romeu-García
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stephen A. Spector
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher R. Sudfeld
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark W. Tenforde
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Toyin O. Togun
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rosa Yataco
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zibiao Zhang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Megan B. Murray
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

ABSTRACT

Background Few studies have evaluated the association between pre-existing vitamin D deficiency (VDD) and incident TB. We assessed the impact of baseline vitamin D on TB risk.

Methods We assessed the association between baseline vitamin D and incident TB in a prospective cohort of 6751 household contacts of TB patients in Peru. We also conducted a one-stage individual participant data meta-analysis searching PubMed and Embase for studies of vitamin D and TB until December 31, 2017. We included studies that assessed vitamin D before TB diagnosis. We defined VDD as 25–(OH)D <50 nmol/L, insufficiency as 50–75 nmol/L and sufficiency as >75nmol/L. We estimated the association between vitamin D and incident TB using conditional logistic regression in the Peru cohort and generalized linear mixed models in the meta-analysis.

Findings In Peru, baseline VDD was associated with a statistically insignificant increase in incident TB (aOR 1·70, 95% CI 0·84–3·46; p=0·14). We identified seven studies for the meta-analysis and analyzed 3544 participants. Individuals with VDD and very low vitamin D (<25nmol/L) had increased TB risk (aOR 1·48, 95% CI 1·04–210;p=0· 03 and aOR 2 08, 95% CI 0·88–4·92; p trend=002 respectively). Among HIV-positive patients, VDD and very low vitamin D conferred a 2-fold (aOR 2.18, 95% CI 1· 22–3·90; p=0· 01) and 4-fold (aOR 4·28, 95% CI 0·85–21·44; p trend=0·01) increased risk of TB respectively.

Interpretation Our findings suggest vitamin D predicts TB risk in a dose-dependent manner and vitamin D supplementation may play a role in TB prevention.

Funding National Institute of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), National Institute on Drug Abuse (NIDA), National Institute of Mental Health (NIMH), International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Dental and Craniofacial Research (NIDCR), Boehringer-Ingelheim, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Foundation, Ujala Foundation, Wyncote Foundation, NIH - Fogarty International Center Program of International Training Grants in Epidemiology Related to AIDS, NIAID Byramjee Jeejeebhoy Medical College HIV Clinical Trials Unit, NIAID’s Baltimore-Washington-India Clinical Trials Unit, National Commission on Biotechnology, the Higher Education Commission, International Research Support Initiative Program of the Higher Education Commission Government of Pakistan, the Bill and Melinda Gates Foundation, and the NIH Fogarty International Center.

Evidence before this study Numerous studies have found lower serum vitamin D levels among patients with active TB disease compared to healthy controls. However, research has not clarified whether low vitamin D increases TB risk or whether TB disease leads to decreased vitamin D levels. We conducted PubMed and Medline searches for all studies available through December 31, 2017 on the association between vitamin D status and TB disease. We included the following keywords: “vitamin D,” “vitamin D deficiency,” “hypovitaminosis D,” “25-hydroxyvitamin D,” “1,25-dihydroxyvitamin D,” “vitamin D2,” “vitamin D3,” “ergocalciferol,” “cholecalciferol,” and “tuberculosis.” We found only seven studies had prospectively evaluated the impact of baseline vitamin D levels on risk of progression to TB disease.

We report here the results of a case control study nested within a large prospective longitudinal cohort study of household contacts of TB cases and the results of an individual participant data (IPD) metaanalysis of available evidence on the association between vitamin D levels and incident TB disease.

Added value of this study We demonstrated that low vitamin D levels predicts risk of future progression to TB disease in a dose-dependent manner.

Implications of all the available evidence These findings suggest the possibility that vitamin D supplementation among individuals at high risk for developing TB disease might play a role in TB prevention efforts.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted January 23, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Vitamin D status and risk of incident tuberculosis disease: a systematic review and individual participant data meta-analysis
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Vitamin D status and risk of incident tuberculosis disease: a systematic review and individual participant data meta-analysis
Omowunmi Aibana, Chuan-Chin Huang, Said Aboud, Alberto Arnedo-Pena, Mercedes C. Becerra, Juan Bautista Bellido-Blasco, Ramesh Bhosale, Roger Calderon, Silvia Chiang, Carmen Contreras, Ganmaa Davaasambuu, Wafaie W. Fawzi, Molly F. Franke, Jerome T. Galea, Daniel Garcia-Ferrer, Maria Gil-Fortuño, Barbará Gomila-Sard, Amita Gupta, Nikhil Gupte, Rabia Hussain, Jesus Iborra-Millet, Najeeha T. Iqbal, Jose Vicente Juan-Cerdán, Aarti Kinikar, Leonid Lecca, Vidya Mave, Noemi Meseguer-Ferrer, Grace Montepiedra, Ferdinand M. Mugusi, Olumuyiwa A. Owolabi, Julie Parsonnet, Freddy Roach-Poblete, Maria Angeles Romeu-García, Stephen A. Spector, Christopher R. Sudfeld, Mark W. Tenforde, Toyin O. Togun, Rosa Yataco, Zibiao Zhang, Megan B. Murray
bioRxiv 481739; doi: https://doi.org/10.1101/481739
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Vitamin D status and risk of incident tuberculosis disease: a systematic review and individual participant data meta-analysis
Omowunmi Aibana, Chuan-Chin Huang, Said Aboud, Alberto Arnedo-Pena, Mercedes C. Becerra, Juan Bautista Bellido-Blasco, Ramesh Bhosale, Roger Calderon, Silvia Chiang, Carmen Contreras, Ganmaa Davaasambuu, Wafaie W. Fawzi, Molly F. Franke, Jerome T. Galea, Daniel Garcia-Ferrer, Maria Gil-Fortuño, Barbará Gomila-Sard, Amita Gupta, Nikhil Gupte, Rabia Hussain, Jesus Iborra-Millet, Najeeha T. Iqbal, Jose Vicente Juan-Cerdán, Aarti Kinikar, Leonid Lecca, Vidya Mave, Noemi Meseguer-Ferrer, Grace Montepiedra, Ferdinand M. Mugusi, Olumuyiwa A. Owolabi, Julie Parsonnet, Freddy Roach-Poblete, Maria Angeles Romeu-García, Stephen A. Spector, Christopher R. Sudfeld, Mark W. Tenforde, Toyin O. Togun, Rosa Yataco, Zibiao Zhang, Megan B. Murray
bioRxiv 481739; doi: https://doi.org/10.1101/481739

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Epidemiology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4383)
  • Biochemistry (9602)
  • Bioengineering (7097)
  • Bioinformatics (24869)
  • Biophysics (12624)
  • Cancer Biology (9962)
  • Cell Biology (14361)
  • Clinical Trials (138)
  • Developmental Biology (7961)
  • Ecology (12111)
  • Epidemiology (2067)
  • Evolutionary Biology (15990)
  • Genetics (10929)
  • Genomics (14745)
  • Immunology (9871)
  • Microbiology (23681)
  • Molecular Biology (9486)
  • Neuroscience (50889)
  • Paleontology (369)
  • Pathology (1540)
  • Pharmacology and Toxicology (2683)
  • Physiology (4019)
  • Plant Biology (8657)
  • Scientific Communication and Education (1510)
  • Synthetic Biology (2397)
  • Systems Biology (6440)
  • Zoology (1346)