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Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function, drug penetration, and antibody shuttling properties
Tae-Eun Park, View ORCID ProfileNur Mustafaoglu, Anna Herland, Ryan Hasselkus, Robert Mannix, Edward A. FitzGerald, Rachelle Prantil-Baun, Alexander Watters, Olivier Henry, Maximilian Benz, Henry Sanchez, Heather J. McCrea, Liliana Christova Goumnerova, Hannah W. Song, Sean P. Palecek, Eric Shusta, Donald E. Ingber
doi: https://doi.org/10.1101/482463
Tae-Eun Park
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
Nur Mustafaoglu
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
Anna Herland
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
Ryan Hasselkus
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
Robert Mannix
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
5Vascular Biology Program and Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA
Edward A. FitzGerald
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
Rachelle Prantil-Baun
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
Alexander Watters
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
Olivier Henry
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
Maximilian Benz
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
Henry Sanchez
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
Heather J. McCrea
2Department of Neurosurgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA
Liliana Christova Goumnerova
2Department of Neurosurgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA
Hannah W. Song
3Department of Chemical and Biological Engineering, University of Wisconsin-Madison
Sean P. Palecek
3Department of Chemical and Biological Engineering, University of Wisconsin-Madison
Eric Shusta
3Department of Chemical and Biological Engineering, University of Wisconsin-Madison
Donald E. Ingber
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
4Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
5Vascular Biology Program and Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA
Posted November 29, 2018.
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function, drug penetration, and antibody shuttling properties
Tae-Eun Park, Nur Mustafaoglu, Anna Herland, Ryan Hasselkus, Robert Mannix, Edward A. FitzGerald, Rachelle Prantil-Baun, Alexander Watters, Olivier Henry, Maximilian Benz, Henry Sanchez, Heather J. McCrea, Liliana Christova Goumnerova, Hannah W. Song, Sean P. Palecek, Eric Shusta, Donald E. Ingber
bioRxiv 482463; doi: https://doi.org/10.1101/482463
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function, drug penetration, and antibody shuttling properties
Tae-Eun Park, Nur Mustafaoglu, Anna Herland, Ryan Hasselkus, Robert Mannix, Edward A. FitzGerald, Rachelle Prantil-Baun, Alexander Watters, Olivier Henry, Maximilian Benz, Henry Sanchez, Heather J. McCrea, Liliana Christova Goumnerova, Hannah W. Song, Sean P. Palecek, Eric Shusta, Donald E. Ingber
bioRxiv 482463; doi: https://doi.org/10.1101/482463
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