Summary
Ninety-three participants with poorly controlled type 2 diabetes despite optimized drug therapy were randomised to receive intensive dietary advice or usual care for six months. Following dietary intervention a significant reduction in interleukin-18 levels was observed, with a ratio of change (95% CI) of 0.90 (0.82-0.99); p = 0.033. Changes in IL-18 correlated with changes in neopterin, r = 0.299 (p = 0.009)
- Abbreviations
- CRP
- C-reactive protein
- IL-6/10/18
- interleukins 6 10 or 18
- IL-18BP
- interleukin-18 binding protein
- TNFα
- tumour necrosis factor alpha
- sTNF-R1/2
- soluble tumour necrosis factor receptors 1 or 2
- IFN-γ
- interferon gamma
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
Posted December 07, 2018.
The effect of dietary intervention on inflammatory markers in patients with type 2 diabetes. An analysis of the Lifestyle Over and Above Drugs in Diabetes (LOADD) study
