Article Information
History
- December 1, 2018.
Article Versions
- Version 1 (November 30, 2018 - 17:39).
- You are currently viewing Version 2 of this article (December 1, 2018 - 18:10).
- View Version 3, the most recent version of this article.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- F. Kyle Satterstrom1,2,3,*,
- Jack A. Kosmicki1,2,3,4,5,*,
- Jiebiao Wang6,*,
- Michael S. Breen7,8,9,
- Silvia De Rubeis7,8,9,†,
- Joon-Yong An10,
- Minshi Peng6,
- Ryan Collins5,11,
- Jakob Grove12,13,14,
- Lambertus Klei15,
- Christine Stevens1,3,4,5,
- Jennifer Reichert7,8,
- Maureen S. Mulhern7,8,
- Mykyta Artomov1,3,4,5,
- Sherif Gerges1,3,4,5,
- Brooke Sheppard10,
- Xinyi Xu7,8,
- Aparna Bhaduri16,17,
- Utku Norman18,
- Harrison Brand5,
- Grace Schwartz10,
- Rachel Nguyen19,
- Elizabeth E. Guerrero20,
- Caroline Dias21,22,
- Branko Aleksic23,
- Richard Anney24,
- Mafalda Barbosa9,
- Somer Bishop10,
- Alfredo Brusco25,26,
- Jonas Bybjerg-Grauholm12,27,
- Angel Carracedo28,29,
- Marcus C.Y. Chan30,
- Andreas G. Chiocchetti31,
- Brian H. Y. Chung30,
- Hilary Coon32,33,
- Michael L. Cuccaro34,
- Aurora Currò35,
- Bernardo Dalla Bernardina36,
- Ryan Doan21,
- Enrico Domenici37,
- Shan Dong10,
- Chiara Fallerini35,
- Montserrat Fernández-Prieto28,38,
- Giovanni Battista Ferrero39,
- Christine M. Freitag31,
- Menachem Fromer3,
- J. Jay Gargus19,
- Daniel Geschwind40,41,
- Elisa Giorgio25,
- Javier González-Peñas42,
- Stephen Guter43,
- Danielle Halpern7,8,
- Emily Hansen-Kiss44,
- Xin He45,
- Gail E. Herman44,
- Irva Hertz-Picciotto20,
- David M. Hougaard12,27,
- Christina M. Hultman46,
- Iuliana Ionita-Laza47,
- Suma Jacob43,
- Jesslyn Jamison7,8,
- Astanand Jugessur48,
- Miia Kaartinen49,
- Gun Peggy Knudsen48,
- Alexander Kolevzon7,8,50,
- Itaru Kushima23,
- So Lun Lee30,
- Terho Lehtimäki51,
- Elaine T. Lim4,
- Carla Lintas52,
- W. Ian Lipkin47,
- Diego Lopergolo35,
- Fátima Lopes53,
- Yunin Ludena20,
- Patricia Maciel53,
- Per Magnus48,
- Behrang Mahjani7,8,
- Nell Maltman43,
- Dara S. Manoach54,
- Gal Meiri55,
- Idan Menashe56,
- Judith Miller32,33,
- Nancy Minshew15,
- Eduarda Montenegro M. de Souza57,
- Danielle Moreira57,
- Eric M. Morrow58,
- Ole Mors12,59,
- Preben Bo Mortensen12,13,60,61,
- Matthew Mosconi43,
- Pierandrea Muglia62,
- Benjamin Neale1,2,3,
- Merete Nordentoft12,63,
- Norio Ozaki23,
- Aarno Palotie2,3,64,65,
- Mara Parellada42,
- Maria Rita Passos-Bueno57,
- Margaret Pericak-Vance34,
- Antonio Persico66,67,
- Isaac Pessah20,
- Kaija Puura49,
- Abraham Reichenberg7,8,9,68,
- Alessandra Renieri35,69,
- Evelise Riberi39,
- Elise B. Robinson1,2,3,
- Kaitlin E. Samocha70,
- Sven Sandin7,8,46,
- Susan L. Santangelo71,72,
- Gerry Schellenberg73,
- Stephen W. Scherer74,75,
- Sabine Schlitt31,
- Rebecca Schmidt20,
- Lauren Schmitt43,
- Isabela Maya W. Silva57,
- Tarjinder Singh1,2,3,4,5,
- Paige M. Siper7,8,9,
- Moyra Smith19,
- Gabriela Soares76,
- Camilla Stoltenberg48,
- Pål Suren48,
- Ezra Susser77,78,
- John Sweeney43,
- Peter Szatmari79,
- Lara Tang7,8,
- Flora Tassone20,80,
- Karoline Teufel31,
- Elisabetta Trabetti81,
- Maria del Pilar Trelles7,8,
- Christopher Walsh21,
- Lauren A. Weiss10,
- Thomas Werge12,82,83,
- Donna Werling10,
- Emilie M. Wigdor1,2,3,
- Emma Wilkinson7,8,
- Jeremy A. Willsey10,
- Tim Yu21,
- Mullin H.C. Yu30,
- Ryan Yuen74,
- Elaine Zachi57,
- iPSYCH consortium,
- Catalina Betancur84,†,
- Edwin H. Cook43,†,
- Louise Gallagher85,†,
- Michael Gill85,†,
- Thomas Lehner86,
- Geetha Senthil86,
- James S. Sutcliffe87,88,†,
- Audrey Thurm86,
- Michael E. Zwick89,†,
- Anders D. Børglum12,13,14,90,
- Matthew W. State10,
- A. Ercument Cicek6,18,
- Michael E. Talkowski5,
- David J. Cutler89,
- Bernie Devlin15,†,#,
- Stephan J. Sanders10,§,
- Kathryn Roeder6,91,†,#,§,
- Joseph D. Buxbaum7,8,9,92,93,94,†,#,§ and
- Mark J. Daly1,2,3,4,5,64,†,#,§
- 1Stanley Center for Psychiatric Research, Broad Institute, Cambridge, Massachusetts, USA
- 2Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
- 3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
- 4Harvard Medical School, Boston, Massachusetts, USA
- 5Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
- 6Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
- 7Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- 8Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- 9The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- 10Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA
- 11Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, Massachusetts, USA
- 12The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark
- 13Center for Genomics and Personalized Medicine, Aarhus, Denmark
- 14Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark
- 15Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
- 16Department of Neurology, University of California San Francisco, San Francisco, California, USA
- 17The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California, USA
- 18Computer Engineering Department, Bilkent University, Ankara, Turkey
- 19Center for Autism Research and Translation, University of California Irvine, Irvine, California, USA
- 20MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis, Davis, California, USA
- 21Division of Genetics, Boston Children’s Hospital, Boston, Massachusetts, USA
- 22Division of Developmental Medicine, Boston Children’s Hospital, Boston, Massachusetts, USA
- 23Department of Psychiatry, Graduate School of Medicine, Nagoya University, Nagoya, Japan
- 24Division of Psychological Medicine & Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom
- 25Department of Medical Sciences, University of Torino, Turin, Italy
- 26Medical Genetics Unit, Città della Salute e della Scienza Hospital, Turin, Italy
- 27Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark
- 28Grupo de Medicina Xenómica, Centro de Investigaciónen en Red de Enfermedades Raras (CIBERER), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
- 29Fundación Pública Galega de Medicina Xenómica, Servicio Galego de Saúde (SERGAS), Santiago de Compostela, Spain
- 30Department of Pediatrics & Adolescent Medicine, Duchess of Kent Children’s Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
- 31Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany
- 32Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
- 33Department of Psychiatry, University of Utah, Salt Lake City, Utah, USA
- 34John P Hussman Institute for Human Genomics, University of Miami, Miami, USA
- 35Medical Genetics, University of Siena, Siena, Italy
- 36Child Neuropsychiatry Department, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics University of Verona, Verona, Italy
- 37Centre for Integrative Biology, University of Trento, Trento, Italy
- 38Neurogenetics Group, Instituto de Investigación Sanitaria de Santiago (IDIS-SERGAS), Santiago de Compostela, Spain
- 39Department of Public Health and Pediatrics, University of Torino, Turin, Italy
- 40Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
- 41Center for Autism Research and Treatment and Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
- 42Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine Complutense University, Madrid, Spain
- 43Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
- 44The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, USA
- 45Department of Human Genetics, University of Chicago, Chicago, Illinois, USA
- 46Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- 47Department of Biostatistics, Columbia University, New York, New York, USA
- 48Norwegian Institute of Public Health, Oslo, Norway
- 49Department of Child Psychiatry, University of Tampere and Tampere University Hospital, Tampere, Finland
- 50Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- 51Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center- Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
- 52Campus Bio-medico, Rome, Italy
- 53Life and Health Sciences Research Institute, School of Medicine, University of Minho, Campus de Gualtar, Braga, Portugal
- 54Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
- 55Pre-School Psychiatry Unit, Soroka University Medical Center, Beer Sheva, Israel
- 56Department of Public Health, Ben-Gurion University of the Negev, Beer-Sheva, Israel
- 57Centro de Pesquisas sobre o Genoma Humano e Células tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil
- 58Department of Molecular Biology, Cell Biology and Biochemistry and Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA
- 59Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark
- 60National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark
- 61Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark
- 62UCB Pharma, Belgium
- 63Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark
- 64Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
- 65Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
- 66Interdepartmental Program “Autism 0-90”, Gaetano Martino University Hospital, University of Messina, Messina, Italy
- 67Mafalda Luce Center for Pervasive Developmental Disorders, Milan, Italy
- 68Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- 69Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy
- 70The Wellcome Trust Sanger Institute, Cambridge, United Kingdom
- 71Maine Medical Center and Maine Medical Center Research Institute, Portland, Maine, USA
- 72Department of Psychiatry, Tufts University School of Medicine, Boston, Massachusetts, USA
- 73Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
- 74Program in Genetics and Genome Biology, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada
- 75McLaughlin Centre, University of Toronto, Toronto, Ontario, Canada
- 76Center for Medical Genetics Dr Jacinto Magalhães, National Health Institute Dr. Ricardo Jorge, Porto, Portugal
- 77New York State Psychiatric Institute, New York, New York, USA
- 78Department of Epidemiology, Mailman School of Public Health, Columbia University, Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
- 79Department of Psychiatry and Behavioural Neurosciences, Offord Centre for Child Studies, McMaster University, Hamilton, Ontario, Canada
- 80Department of Biochemistry and Molecular Medicine, University of California Davis, School of Medicine, Davis, CA, USA
- 81Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, Verona, Italy
- 82Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark
- 83Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
- 84Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine, Institut de Biologie Paris Seine, Paris, France
- 85Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland
- 86National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
- 87Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
- 88Department of Molecular Physiology and Biophsysics and Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
- 89Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
- 90Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark
- 91Computational Biology Department, Carnegie Mellon University, Pittsburgh,Pennsylvania, USA
- 92Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- 93Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- 94Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA