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Dengue and Chikungunya among Febrile Outpatients in Kinshasa, Democratic Republic of Congo: a cross-sectional study

View ORCID ProfileSam Proesmans, Freddy Katshongo, John Milambu, Blaise Fungula, Hypolite Muhindo Mavoko, Steve Ahuka-Mundeke, Raquel Inocêncio da Luz, Marjan Van Esbroeck, Kevin K. Ariën, Lieselotte Cnops, Birgit De Smet, Pascal Lutumba, Jean-Pierre Van geertruyden, Veerle Vanlerberghe
doi: https://doi.org/10.1101/486407
Sam Proesmans
1University of Antwerp, Belgium
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Freddy Katshongo
2Institut Supérieur des Techniques Médicales, Democratic Republic of Congo
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John Milambu
3Centre Hospitalier Lisungi, Democratic Republic of Congo
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Blaise Fungula
3Centre Hospitalier Lisungi, Democratic Republic of Congo
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Hypolite Muhindo Mavoko
1University of Antwerp, Belgium
4University of Kinshasa, Democratic Republic of Congo
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Steve Ahuka-Mundeke
4University of Kinshasa, Democratic Republic of Congo
5Institut National de Reserche Biomédicale, Kinshasa, Democratic Republic of Congo
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Raquel Inocêncio da Luz
6Institute of Tropical Medicine Antwerp, Belgium
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Marjan Van Esbroeck
6Institute of Tropical Medicine Antwerp, Belgium
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Kevin K. Ariën
1University of Antwerp, Belgium
6Institute of Tropical Medicine Antwerp, Belgium
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Lieselotte Cnops
6Institute of Tropical Medicine Antwerp, Belgium
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Birgit De Smet
6Institute of Tropical Medicine Antwerp, Belgium
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Pascal Lutumba
4University of Kinshasa, Democratic Republic of Congo
5Institut National de Reserche Biomédicale, Kinshasa, Democratic Republic of Congo
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Jean-Pierre Van geertruyden
1University of Antwerp, Belgium
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Veerle Vanlerberghe
6Institute of Tropical Medicine Antwerp, Belgium
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Abstract

Background Pathogens causing acute fever, with the exception of malaria, remain largely unidentified in sub-Saharan Africa, given the local unavailability of diagnostic tests and the broad differential diagnosis.

Methodology/Principal Findings We conducted a cross-sectional study including outpatient acute febrile syndromes in both children and adults, between November 2015 and June 2016 in Kinshasa, Democratic Republic of Congo. Serological and molecular diagnostic tests for arboviral infections were performed on blood, including PCR and NS1-RDT for acute, and ELISA and IFAT for past infections.

Conclusions/Significance Among 342 patients, aged 2 to 68 years, 45.3% tested positive on malaria Rapid Diagnostic Test. However, 87.7% received antimalarial and 64.3% antibacterial treatment. Further investigation among 235 fever cases revealed 19 (8.1%) acute dengue and 2 (0.9%) acute chikungunya infections, with an important proportion of participants already exposed to flaviviridae (possibly dengue) and alphaviridae (possibly chikungunya) in the past, namely 30.2 % and 26.4% respectively. We found no evidence of exposure to Zika nor yellow fever virus.

Author Summary Sam Proesmans is a medical doctor, currently doing a fellowship in internal medicine at the University of Antwerp, Belgium. He holds a Master of Public Health from Columbia University, New York City, USA. His primary research interest lies in infectious diseases, from a public health point of view and he believes that this study is proof that the differential diagnosis should include arboviral infection, given the hitherto unseen evidence of high arbivirus infection rates in the Democratic Republic of Congo, in that they are mostly misdiagnosed as malaria or bacterial infections.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted December 03, 2018.
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Dengue and Chikungunya among Febrile Outpatients in Kinshasa, Democratic Republic of Congo: a cross-sectional study
Sam Proesmans, Freddy Katshongo, John Milambu, Blaise Fungula, Hypolite Muhindo Mavoko, Steve Ahuka-Mundeke, Raquel Inocêncio da Luz, Marjan Van Esbroeck, Kevin K. Ariën, Lieselotte Cnops, Birgit De Smet, Pascal Lutumba, Jean-Pierre Van geertruyden, Veerle Vanlerberghe
bioRxiv 486407; doi: https://doi.org/10.1101/486407
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Dengue and Chikungunya among Febrile Outpatients in Kinshasa, Democratic Republic of Congo: a cross-sectional study
Sam Proesmans, Freddy Katshongo, John Milambu, Blaise Fungula, Hypolite Muhindo Mavoko, Steve Ahuka-Mundeke, Raquel Inocêncio da Luz, Marjan Van Esbroeck, Kevin K. Ariën, Lieselotte Cnops, Birgit De Smet, Pascal Lutumba, Jean-Pierre Van geertruyden, Veerle Vanlerberghe
bioRxiv 486407; doi: https://doi.org/10.1101/486407

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