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Symmetry breaking in the embryonic skin triggers a directional and sequential front of competence during plumage patterning

Richard Bailleul, Carole Desmarquet-Trin Dinh, Magdalena Hidalgo, Camille Curantz, Jonathan Touboul, Marie Manceau
doi: https://doi.org/10.1101/491092
Richard Bailleul
1Center for Interdisciplinary Research in Biology, CNRS UMR7040, INSERM U1050, Collège de France, Paris
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Carole Desmarquet-Trin Dinh
1Center for Interdisciplinary Research in Biology, CNRS UMR7040, INSERM U1050, Collège de France, Paris
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Magdalena Hidalgo
1Center for Interdisciplinary Research in Biology, CNRS UMR7040, INSERM U1050, Collège de France, Paris
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Camille Curantz
1Center for Interdisciplinary Research in Biology, CNRS UMR7040, INSERM U1050, Collège de France, Paris
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Jonathan Touboul
2Department of Mathematics and Volen National Center for Complex Systems, Brandeis University, Waltham, MA
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Marie Manceau
1Center for Interdisciplinary Research in Biology, CNRS UMR7040, INSERM U1050, Collège de France, Paris
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ABSTRACT

The development of an organism involves the formation of patterns from initially homogeneous surfaces in a reproducible manner. Simulations of various theoretical models recapitulate final states of natural patterns1-4 yet drawing testable hypotheses from those often remains difficult4,5. Consequently, little is known on pattern-forming events. Here, we extend modeling to reproduce not only the final plumage pattern of birds, but also the observed natural variation in its dynamics of emergence in five species. We built a unified model intrinsically generating the directionality, sequence, and duration of patterning, and used in vivo experiments to test its parameter-based predictions. We showed that while patterning duration is controlled by overall cell proliferation, its directional and sequential progression result from a pre-pattern: an initial break in surface symmetry launches a traveling front of increased cell density that defines domains with self-organizing capacity. These results show that universal mechanisms combining pre-patterning and self-organization govern the timely emergence of the plumage pattern in birds.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted December 08, 2018.
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Symmetry breaking in the embryonic skin triggers a directional and sequential front of competence during plumage patterning
Richard Bailleul, Carole Desmarquet-Trin Dinh, Magdalena Hidalgo, Camille Curantz, Jonathan Touboul, Marie Manceau
bioRxiv 491092; doi: https://doi.org/10.1101/491092
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Symmetry breaking in the embryonic skin triggers a directional and sequential front of competence during plumage patterning
Richard Bailleul, Carole Desmarquet-Trin Dinh, Magdalena Hidalgo, Camille Curantz, Jonathan Touboul, Marie Manceau
bioRxiv 491092; doi: https://doi.org/10.1101/491092

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