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Structure of a cytochrome-based bacterial nanowire

David J. Filman, Stephen F. Marino, Joy E. Ward, Lu Yang, Zoltán Mester, Esther Bullitt, Derek R. Lovley, Mike Strauss
doi: https://doi.org/10.1101/492645
David J. Filman
1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School 240 Longwood Avenue, Boston MA 02115; 617/432-3919;
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  • For correspondence: david_filman@hms.harvard.edu
Stephen F. Marino
2German Federal Institute of Risk Assessment, Unit Microbial Toxins, Department of Biological Safety, Max-Dohrn-Str. 8–10, 10589 Berlin, Germany, Tel. 49 30-18412-24418,
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  • For correspondence: Stephen-F.Marino@bfr.bund.de
Joy E. Ward
3Department of Microbiology and Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA 01002; 413-695-1690; ,
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  • For correspondence: jward@microbio.umass.edu dlovley@microbio.umass.edu
Lu Yang
4National Research Council Canada, 1200 Montreal Road Ottawa, ON, Canada +1 613 9935008,
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  • For correspondence: Zoltan.mester@nrc.ca
Zoltán Mester
4National Research Council Canada, 1200 Montreal Road Ottawa, ON, Canada +1 613 9935008,
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  • For correspondence: Zoltan.mester@nrc.ca
Esther Bullitt
5Department of Physiology & Biophysics, Boston University School of Medicine, 700 Albany Street, Boston MA; 617-358-8464;
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  • For correspondence: bullitt@bu.edu
Derek R. Lovley
3Department of Microbiology and Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA 01002; 413-695-1690; ,
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  • For correspondence: jward@microbio.umass.edu dlovley@microbio.umass.edu
Mike Strauss
6Department of Anatomy and Cell Biology, McGill University, 3640 University St, Montreal, Canada; 514-398-8084;
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  • For correspondence: mike.strauss@mcgill.ca mike.strauss@mcgill.ca
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Abstract

Electrically conductive pili from Geobacter species, termed bacterial “nanowires”, are intensely studied for their biological significance and potential in the development of new materials. We have characterized a unique nanowire from conductive G. sulfurreducens pili preparations by cryo-electron microscopy composed solely of the c-type cytochrome OmcS. We present here, at 3.4 Å resolution, a novel structure of a cytochrome-based filament and discuss its possible role in long-range biological electron transport.

Summary sentence Cryo-electron microscopy reveals the remarkable assembly of a c-type cytochrome into filaments comprising a heme-based bacterial nanowire.

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Posted December 10, 2018.
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Structure of a cytochrome-based bacterial nanowire
David J. Filman, Stephen F. Marino, Joy E. Ward, Lu Yang, Zoltán Mester, Esther Bullitt, Derek R. Lovley, Mike Strauss
bioRxiv 492645; doi: https://doi.org/10.1101/492645
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Structure of a cytochrome-based bacterial nanowire
David J. Filman, Stephen F. Marino, Joy E. Ward, Lu Yang, Zoltán Mester, Esther Bullitt, Derek R. Lovley, Mike Strauss
bioRxiv 492645; doi: https://doi.org/10.1101/492645

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