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Quantification of microenvironmental metabolites in murine cancer models reveals determinants of tumor nutrient availability

Mark R. Sullivan, Laura V. Danai, Caroline A. Lewis, Sze Ham Chan, Dan Y. Gui, Tenzin Kunchok, Emily A. Dennstedt, Matthew G. Vander Heiden, Alexander Muir
doi: https://doi.org/10.1101/492652
Mark R. Sullivan
1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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Laura V. Danai
1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
2Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Amherst, MA 01003, USA
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Caroline A. Lewis
3Department of Biology and Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
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Sze Ham Chan
3Department of Biology and Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
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Dan Y. Gui
1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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Tenzin Kunchok
3Department of Biology and Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
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Emily A. Dennstedt
1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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Matthew G. Vander Heiden
1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
4Dana-Farber Cancer Institute, Boston, MA 02115, USA
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  • For correspondence: amuir@uchicago.edu mvh@mit.edu
Alexander Muir
1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
5Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
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  • For correspondence: amuir@uchicago.edu mvh@mit.edu
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Posted December 10, 2018.
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Quantification of microenvironmental metabolites in murine cancer models reveals determinants of tumor nutrient availability
Mark R. Sullivan, Laura V. Danai, Caroline A. Lewis, Sze Ham Chan, Dan Y. Gui, Tenzin Kunchok, Emily A. Dennstedt, Matthew G. Vander Heiden, Alexander Muir
bioRxiv 492652; doi: https://doi.org/10.1101/492652
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Quantification of microenvironmental metabolites in murine cancer models reveals determinants of tumor nutrient availability
Mark R. Sullivan, Laura V. Danai, Caroline A. Lewis, Sze Ham Chan, Dan Y. Gui, Tenzin Kunchok, Emily A. Dennstedt, Matthew G. Vander Heiden, Alexander Muir
bioRxiv 492652; doi: https://doi.org/10.1101/492652

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