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Mechanistic insights into the evolution of DUF26-containing proteins in land plants

View ORCID ProfileAleksia Vaattovaara, View ORCID ProfileBenjamin Brandt, View ORCID ProfileSitaram Rajaraman, View ORCID ProfileOmid Safronov, View ORCID ProfileAndres Veidenberg, View ORCID ProfileMarkéta Luklová, View ORCID ProfileJaakko Kangasjärvi, View ORCID ProfileAri Löytynoja, View ORCID ProfileMichael Hothorn, View ORCID ProfileJarkko Salojärvi, View ORCID ProfileMichael Wrzaczek
doi: https://doi.org/10.1101/493502
Aleksia Vaattovaara
Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1 (POB65), FI-00014 Helsinki, Finland
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Benjamin Brandt
Structural Plant Biology Laboratory, Department of Botany and Plant Biology, University of Geneva, Geneva, Switzerland
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Sitaram Rajaraman
Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1 (POB65), FI-00014 Helsinki, Finland
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Omid Safronov
Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1 (POB65), FI-00014 Helsinki, Finland
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Andres Veidenberg
Institute of Biotechnology, University of Helsinki, Viikinkaari 1 (POB65), FI-00014 Helsinki, Finland
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Markéta Luklová
Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1 (POB65), FI-00014 Helsinki, Finland
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Jaakko Kangasjärvi
Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1 (POB65), FI-00014 Helsinki, Finland
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Ari Löytynoja
Institute of Biotechnology, University of Helsinki, Viikinkaari 1 (POB65), FI-00014 Helsinki, Finland
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Michael Hothorn
Structural Plant Biology Laboratory, Department of Botany and Plant Biology, University of Geneva, Geneva, Switzerland
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Jarkko Salojärvi
School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, SingaporeOrganismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1 (POB65), FI-00014 Helsinki, Finland
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  • For correspondence: michael.wrzaczek@helsinki.fi jarkko@ntu.edu.sg
Michael Wrzaczek
Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1 (POB65), FI-00014 Helsinki, Finland
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  • For correspondence: michael.wrzaczek@helsinki.fi jarkko@ntu.edu.sg
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Abstract

Large protein families are a prominent feature of plant genomes and their size variation is a key element for adaptation in plants. Here we infer the evolutionary history of a representative protein family, the DOMAIN OF UNKNOWN FUNCTION (DUF) 26-containing proteins. The DUF26 first appeared in secreted proteins. Domain duplications and rearrangements led to the emergence of CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASES (CRKs) and PLASMODESMATA-LOCALIZED PROTEINS (PDLPs). While the DUF26 itself is specific to land plants, structural analyses of Arabidopsis PDLP5 and PDLP8 ectodomains revealed strong similarity to fungal lectins. Therefore, we propose that DUF26-containing proteins constitute a novel group of plant carbohydrate-binding proteins. Following their appearance, CRKs expanded both through tandem duplications and preferential retention of duplicates in whole genome duplication events, whereas PDLPs evolved according to the dosage balance hypothesis. Based on our findings, we suggest that the main mechanism of expansion in new gene families is small-scale duplication, whereas genome fractionation and genetic drift after whole genome multiplications drive families towards dosage balance.

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Posted December 11, 2018.
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Mechanistic insights into the evolution of DUF26-containing proteins in land plants
Aleksia Vaattovaara, Benjamin Brandt, Sitaram Rajaraman, Omid Safronov, Andres Veidenberg, Markéta Luklová, Jaakko Kangasjärvi, Ari Löytynoja, Michael Hothorn, Jarkko Salojärvi, Michael Wrzaczek
bioRxiv 493502; doi: https://doi.org/10.1101/493502
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Mechanistic insights into the evolution of DUF26-containing proteins in land plants
Aleksia Vaattovaara, Benjamin Brandt, Sitaram Rajaraman, Omid Safronov, Andres Veidenberg, Markéta Luklová, Jaakko Kangasjärvi, Ari Löytynoja, Michael Hothorn, Jarkko Salojärvi, Michael Wrzaczek
bioRxiv 493502; doi: https://doi.org/10.1101/493502

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